Parathyroid Hormone-related Peptide Is a Better Indicator of Cancer Treatment Efficacy Than Serum Calcium.

Anticancer ResOct 28, 2026
Case ReportOncology (Medical)Endocrinology

Jerome H Check

✦ AI-curated · Sources linked

Case in brief

A 66-year-old woman with extensive cutaneous squamous cell carcinoma of the scalp, unsuitable for primary surgical removal, received cemiplimab. She was hospitalized with severe hypercalcemia while awaiting treatment approval. After the second course, serum calcium had fallen to the low-normal range, but PTHrP had risen markedly. Imaging subsequently demonstrated rapid progression with bone, brain, lung, and liver metastases, and she died shortly thereafter.

What made this case unusual

Serum calcium appeared to improve during treatment while PTHrP rose markedly; subsequent imaging showed rapid metastatic progression.

Diagnostic / clinical pearl

In PTHrP-mediated hypercalcemia, a falling or normalized serum calcium may not reflect cancer control. Serial PTHrP measurement may provide additional information about treatment efficacy.

Source

PubMed · PMID 42946438

Published in Anticancer Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Oncology (Medical)

Clinical ResearchVascular SurgeryOpen access

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

This prespecified cognitive-outcomes analysis of the multicentre, randomised CREST-2 trials assessed patients aged 35 years or older with at least 70% asymptomatic carotid stenosis.

JAMAOct 27, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.

This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.

JAMAOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.