Sequential Lidocaine and Liposomal Bupivacaine for Popliteal Sciatic Nerve Block in Foot and Ankle Surgery: A Randomized Controlled Trial.
Zhiyi Cheng, Yanling Hu, Cheng Xu et al.
✦ AI-curated · Sources linked
From the abstract
In foot and ankle surgery, prolonged analgesia after popliteal sciatic nerve block (PSNB) may be accompanied by delayed motor recovery. The effects of sequential lidocaine and liposomal bupivacaine (LB), particularly on early motor function, remain uncertain.
Reported results
In complete-case analyses, 37 lidocaine-LB and 38 ropivacaine recipients were included. Median (IQR) 24-hour resting pain was 0 (0-2) versus 1 (0-3) (difference, -1; 95% CI, -3 to 0; P<0.001); the difference was below the prespecified 1.5-point threshold for clinical importance. The 3-hour motor score was 1 (1-1) versus 0 (0-0) (difference, 1; 95% CI, 1 to 1; P<0.001), meeting the study-defined 1-point threshold.
Authors' conclusions
Compared with single-injection ropivacaine, sequential lidocaine-LB was associated with better early motor scores and statistically lower 24-hour resting pain. The pain difference did not meet the prespecified threshold for clinical importance. Functional benefit and comparative safety remain unestablished.