A Moisturizer With Centella asiatica and Mandelic Acid Reduces Bruising and Speeds Recovery in Mature Skin.

J Drugs DermatolNov 1, 2026
Clinical ResearchDermatology

Todd Schlesinger, Glynis Ablon, Alan Widgerow et al.

✦ AI-curated · Sources linked

In 30 seconds

This 12-week multicenter, randomized, blinded, in-use study evaluated a moisturizer containing Centella asiatica and mandelic acid in men and women aged 40 to 60 years with fragile, bruise-prone skin. Participants applied the cream twice daily; a subset underwent electric cupping to induce bruising at baseline and week 12. After treatment, investigator-assessed bruise severity was lower than at baseline (mean [SD] 3.27 [1.33] vs 4.13 [1.02]; P=.0087). Bruise resolution was numerically faster, but the difference was not statistically significant. No related adverse events were reported.

Key findings

  • Bruise severity after 12 weeks was lower than at baseline: mean [SD] 3.27 [1.33] vs 4.13 [1.02] (P=.0087).
  • Mean time to bruise resolution was 6.33 [0.91] days at week 12 versus 8.00 [0.56] days at baseline; the difference was not statistically significant (log-rank P=.3134).
  • Subject satisfaction was high, and no related adverse events were reported.

Why it matters

Bruising and delayed recovery are features of fragile, mature skin and can affect skin health. This study suggests that twice-daily use of the tested cream may reduce experimentally induced bruise severity. The observed difference in resolution time was not statistically significant, so evidence for faster recovery is less conclusive.

What to keep in mind

Bruising was experimentally induced in a subset of 15 subjects, and follow-up lasted 12 weeks. The abstract does not report the overall sample size.

Source

PubMed · PMID 42976840

Published in J Drugs Dermatol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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