Unmasking Panic Disorder in Adults with Leukemia: A Systematic Review of Prevalence, Risk Factors, and Management.
Mridul Sarangal
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In 30 seconds
This PRISMA-guided systematic review examined panic disorder and anxiety in adults with leukemia, searching four databases for studies published from 2015 to July 20, 2025. Seven studies involving 1,292 participants reported anxiety prevalence of 15%-39% and panic disorder prevalence of 2%-8%. Younger age and chemotherapy were identified as risk factors. The review also reported CBT and SSRIs as effective management approaches and concluded that panic disorder affects quality of life, supporting routine screening.
Key findings
- Across seven studies (n = 1,292), reported anxiety prevalence ranged from 15%-39%.
- Reported panic disorder prevalence in adults with leukemia was 2%-8%.
- Younger age and chemotherapy were identified as risk factors for anxiety or panic disorder.
- The review reported CBT and SSRIs as effective management approaches.
Why it matters
Anxiety and panic disorder may affect quality of life in adults with leukemia, while symptoms can be relevant during cancer treatment. The review brings together evidence on prevalence, associated factors, and management, highlighting mental health assessment as part of care for this population.
What to keep in mind
The review included only seven studies, and the abstract does not report how many assessed panic disorder specifically or provide details on the strength and consistency of treatment evidence.