Lurasidone Induced Amphibian Like Buccal Oscillations: A Rare Case of Early Onset Tardive Dyskinesia Like Disorder in a Geriatric Patient with Treatment-Resistant Depression.

Psychopharmacol BullOct 30, 2026
Case ReportPsychiatryGeriatricsOpen access

Ravi Chand Sharma, Ramanpreet Kaur

✦ AI-curated · Sources linked

Case in brief

A 64-year-old woman with treatment-resistant depression developed floor-of-mouth movements resembling buccal pumping, along with white spots on the inner lower lip and facial puffiness, within 7 days of starting adjunctive lurasidone 80 mg. The oral mucosal changes and puffiness resolved completely over 5 weeks. The buccal movements improved significantly after tetrabenazine, a vesicular monoamine transporter 2 inhibitor, was titrated.

What made this case unusual

The movement disorder had an amphibian-like buccal-pumping appearance and occurred alongside oral mucosal changes and facial puffiness soon after lurasidone initiation.

Diagnostic / clinical pearl

In geriatric patients receiving atypical antipsychotics, monitor for movement-related adverse effects as well as oral changes and facial swelling.

Source

PubMed · PMID 42979609Free full text on PubMed Central

Published in Psychopharmacol Bull. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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