STAT6-positive solitary fibrous tumour of the lacrimal gland with floret-type giant cells: a rare case report.
Alaa Sonbol, Raghda Tarek, Maha Elzaafarany et al.
✦ AI-curated · Sources linked
Case in brief
A 52-year-old man presented with five months of enlarging left lacrimal swelling, proptosis, and mildly reduced visual acuity. CT showed a well-defined 9 × 12 mm orbital lesion without bone erosion or local invasion. Excision revealed a patternless spindle-cell tumour with staghorn vessels, low mitotic activity, and floret-type multinucleated giant cells, without necrosis or vascular or perineural invasion. CD34, CD99, BCL2, and diffuse nuclear STAT6 expression supported solitary fibrous tumour; margins were negative. At three months, visual function had recovered fully, with no diplopia.
What made this case unusual
The tumour combined floret-type giant-cell morphology with diffuse nuclear STAT6 staining in a lacrimal gland solitary fibrous tumour, a pattern that may overlap with other giant-cell-rich spindle-cell lesions.
Diagnostic / clinical pearl
In a giant-cell-rich spindle-cell lesion of the lacrimal gland, interpret morphology alongside immunohistochemistry; diffuse nuclear STAT6 expression supported solitary fibrous tumour in this case.