Pump-Predicted Ciprofol Ce50 for Suppressing the Cardiovascular Response to Tracheal Intubation During Fixed Sufentanil-Esketamine Induction: An Age-Stratified Dixon Up-and-Down Study.
Xiaofen Lin, Qing Wan, Ruwen Huang et al.
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From the abstract
To estimate the ciprofol pump-predicted effect-site target concentration associated with a 50% probability of suppressing the cardiovascular response to tracheal intubation (Ce50) during fixed sufentanil-esketamine induction in two age cohorts.
Reported results
Thirty-two middle-aged and 21 older adults were analyzed. Midpoint Ce50 was 0.975 μg/mL (approximate 95% confidence interval [CI], 0.910-1.040) and 1.096 μg/mL (1.072-1.121), respectively. Probit Ce50 was 0.991 μg/mL (95% CI, 0.773-1.103) and 1.112 μg/mL (1.078-1.152). At target Ce, mean arterial pressure fell by 19.2% ± 11.0% and 22.5% ± 12.5% from baseline.
Authors' conclusions
These exploratory Ce50 estimates are specific to the CONCERT-III pump model and the studied co-induction and rescue protocol in small, nonrandomized cohorts at a single center. Frequent hypotension and norepinephrine use accompanied induction. The estimates do not establish an independent age effect or individual dosing targets and require external validation.