Delayed pancytopenia following ingestion of wild mushrooms consistent with Hypholoma fasciculare: A case report.
Hyeonbeom Byeon, Juho An
✦ AI-curated · Sources linked
Case in brief
A 57-year-old man presented with fever and generalized weakness about 10 days after eating self-collected wild mushrooms consistent with Hypholoma fasciculare. Testing showed delayed-onset pancytopenia. Infectious, autoimmune, and hematologic investigations, including viral serology and bone marrow examinations, did not identify an alternative cause or evidence of malignancy or aplastic anemia. The clinical course supported toxin-mediated bone marrow suppression as the most plausible explanation. He received close monitoring and supportive care without antidotal or immunosuppressive treatment. Blood counts gradually recovered, with complete resolution and no recurrence during outpatient follow-up.
What made this case unusual
The delayed pancytopenia followed mushroom ingestion despite the absence of severe initial symptoms; hematologic toxicity associated with Hypholoma species is rarely reported.
Diagnostic / clinical pearl
Consider toxin-mediated marrow suppression when pancytopenia develops after wild mushroom ingestion, even if the initial presentation was not severe; exclude alternative causes and monitor blood counts.