Prognostic value of anti-gp210 antibodies in primary biliary cholangitis: A Systematic review and meta-analysis.

Medicine (Baltimore)Nov 6, 2026
Clinical ResearchGastroenterologyPathology (Anatomic & Clinical)

Yazhen Zhang, Yujiao Jin, Miaochan Wang et al.

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In 30 seconds

This systematic review and meta-analysis pooled evidence from 12 records examining the prognostic significance of anti-gp210 antibodies in people with primary biliary cholangitis (PBC). Compared with antibody-negative patients, anti-gp210-positive patients had higher risks of liver failure (RR, 6.11; 95% CI, 3.16-11.81) and mortality (RR, 1.92; 95% CI, 1.55-2.37), and a lower ursodeoxycholic acid response rate (RR, 0.81; 95% CI, 0.73-0.89). Antibody positivity was also independently associated with poor prognosis (HR, 4.53; 95% CI, 2.83-7.26).

Key findings

  • Anti-gp210-positive patients had higher liver failure incidence than antibody-negative patients (RR, 6.11; 95% CI, 3.16-11.81).
  • Mortality was higher in anti-gp210-positive patients (RR, 1.92; 95% CI, 1.55-2.37).
  • The UDCA response rate was lower with anti-gp210 positivity (RR, 0.81; 95% CI, 0.73-0.89).
  • Anti-gp210 positivity was independently associated with poor prognosis (HR, 4.53; 95% CI, 2.83-7.26).

Why it matters

The pooled findings link anti-gp210 positivity with clinically important outcomes, including liver failure and mortality, as well as reduced UDCA response. This supports its potential value as a prognostic marker alongside other clinical information. The associations may help inform risk assessment, while the meta-analysis does not establish that antibody status itself causes poorer outcomes.

Source

PubMed · PMID 42994875

Published in Medicine (Baltimore). This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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