Oliceridine vs Sufentanil Combined With Ondansetron for Postoperative Nausea and Vomiting and QTc Interval in Hysteroscopic Surgery: A Prospective Randomized Controlled Study.
Zhijia Guo, Yanan Wu, Yuqian Sang
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In 30 seconds
This prospective, randomized, double-blind controlled study compared oliceridine plus ondansetron with sufentanil plus ondansetron in 62 patients undergoing non-intubated hysteroscopic surgery under general anesthesia. The primary outcome was postoperative nausea and vomiting (PONV) within 24 hours; QTc changes, emergence time, and recovery-room pain were also assessed. PONV occurred in 0% versus 3.2%, respectively, a difference that was not statistically significant (P>0.05). QTc changes over time were significant, but did not differ significantly by treatment group or group-by-time interaction; the authors reported no clinically significant QTc prolongation.
Key findings
- Twenty-four-hour PONV incidence was 0% with oliceridine and 3.2% with sufentanil (P>0.05).
- For ΔQTc, there was a time effect (P=0.001), but no significant group effect (P=0.076) or group×time interaction (P=0.171).
- Emergence time was comparable (P=0.960), as were PACU discharge pain scores (P=0.186).
Why it matters
The study addresses both nausea prevention and cardiac safety when opioids are used with ondansetron during hysteroscopic anesthesia. Its findings suggest that, in this study population, the two opioid regimens had similar observed PONV and QTc outcomes. The results are useful for understanding these specific combinations, while the small analyzed sample and limited statistical power constrain conclusions about differences between them.
What to keep in mind
Only 62 patients were analyzed, and the authors caution that limited statistical power affects interpretation of the PONV comparison.