Esketamine-Based Versus Sevoflurane-Based Anesthesia with Dexmedetomidine for Emergence Agitation in Pediatric Corneal Suture Removal: A Randomised Controlled Trial.

Drug Des Devel TherNov 6, 2026 (epub)
Case ReportAnesthesiologyOphthalmologyPediatricsOpen access

Wenjing Yi, Tingjie Liu, Jing Chen et al.

✦ AI-curated · Sources linked

Condensed from the publisher's abstract. An xxcode editorial summary of this publication has not been generated yet.

From the abstract

Corneal suture removal, particularly microsurgery requiring complete immobility, demands adequate anesthetic depth while ensuring rapid recovery. Emergence agitation (EA) is a common postoperative complication in children and may compromise recovery quality.

Reported results

The incidence of EA was significantly lower in group E than in group S (6.9% vs 27.6%, RR: 0.25; 95% CI, (0.09 to 0.70); P = 0.003). Group E also showed a lower incidence of respiratory depression (3.4% vs 43.1%, P = 0.001) and a shorter time to discharge from the post-anesthesia care unit (19.50 [8] vs17.00 [5] min, P = 0.02).

Authors' conclusions

Compared with sevoflurane-based anesthesia, esketamine-based anesthesia reduced the incidence of emergence agitation in pediatric patients receiving dexmedetomidine, but hypertension and elevated intraocular pressure were more frequently observed.

Source

PubMed · PMID 43011846Free full text on PubMed Central

Published in Drug Des Devel Ther. The text above is extracted from the publisher's own abstract and has not been edited by xxcode. For clinical decisions, review the original publication.

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