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359 articles
October 202624
Berberine improves diabetic foot ulcer healing after tibial transverse osteotomy by inhibiting the PDGF-B/PDGFRβ signaling pathway .
This prospective, single-centre, randomized, placebo-controlled trial evaluated local berberine injections added to tibial transverse osteotomy (TTO) in patients with Wagner grade 2–4 diabetic foot ulcers.
Safety of low lipoprotein(a) levels: the FOURIER trial.
This analysis of the randomized, multicentre FOURIER trial examined associations between lipoprotein(a) [Lp(a)] levels and safety outcomes in patients with stable atherosclerotic cardiovascular disease receiving…
A randomized study comparing plant sterol- and soluble fiber-enriched soymilk with plain soymilk in adults with elevated LDL cholesterol.
This randomized controlled trial compared plant sterol- and soluble fiber-enriched soymilk with plain soymilk in 242 adults with hypercholesterolemia, untreated or on stable lipid-lowering therapy.
Efficacy and safety of GLP-1 receptor agonists for antipsychotic-related overweight and metabolic dysregulation: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled randomized controlled trials of GLP-1 receptor agonists in adults receiving antipsychotic treatment for overweight or metabolic dysregulation.
Gut virome remodeling after fecal microbiota transplantation is associated with virus-bacteria co-variation and metabolic response in obesity and type 2 diabetes.
This randomized controlled trial examined longitudinal fecal virome and bacteriome changes after fecal microbiota transplantation (FMT) in people with obesity and type 2 diabetes.
The Impact of Telemedicine Interventions on Maternal and Fetal Outcomes in Women With Gestational Diabetes: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis pooled 23 randomized controlled trials involving 3055 women with gestational diabetes to assess telemedicine and maternal and fetal outcomes.
Search for the glycated hemoglobin target minimizing mortality among people with type 2 diabetes with rare incidence of treatment-related severe hypoglycemia - Epidemiologic analysis of J-DOIT3 randomized controlled trial.
This landmark analysis of the J-DOIT3 randomized controlled trial examined associations between updated HbA1c and cardiovascular outcomes or mortality among people with type 2 diabetes, in a setting where severe…
Delayed diagnosis of MEN1 after kidney transplantation: unrecognized pre-transplant features and implications for clinical practice.
A 68-year-old man with end-stage renal disease underwent living-donor kidney transplantation and had persistent hypercalcemia afterward.
Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review.
This systematic review examined randomized evidence on bone mineral density (BMD) and bone-turnover markers in adults with overweight or obesity receiving GLP-1 receptor agonists.
Maternal and Neonatal Complications in Pregnant Women With Polyendocrine Metabolic Ovarian Syndrome: A Nested Prospective Cohort Study.
This prospective nested cohort study examined associations between polyendocrine metabolic ovarian syndrome (PMOS) and pregnancy outcomes among 3,645 pregnant women with risk factors for hyperglycemia enrolled in an…
Excess Liver Fat in Type 2 Diabetes Stratified by Intrapancreatic Fat Deposition: A Meta-Analysis of Dual-Organ MRI Studies.
This meta-analysis pooled dual-organ MRI studies comparing liver fat content (LFC) in people with type 2 diabetes (T2DM) and non-diabetic controls, and examined whether study-level intrapancreatic fat deposition (IPFD)…
From Alert to Action: Electronic Practice Advisory Improves DSMES Referrals Over 18 Months.
This cluster-randomized controlled trial in primary care practices in central North Carolina tested whether an electronic health record best practice advisory (BPA) increased referrals to diabetes self-management…
Calorie-Restricted DASH, Carbohydrate-Restricted, and Low-Purine Diets for Weight Loss and Urate Control in Men With Overweight or Obesity and Hyperuricemia: A Randomized Trial.
This 12-week, open-label, active-comparator randomized trial compared calorie-restricted carbohydrate-restricted, DASH, and low-purine balanced diets in 102 men with overweight or obesity and hyperuricemia.
The Effect of Obesity on the α-Cell Response to Hyperglycemia in the Presence of Amino Acids.
This randomized, two-occasion study examined how amino acids affect glucagon suppression during graded glucose infusion in lean participants and participants with obesity, with or without hepatic steatosis.
Evaluating Improvement in Pain and Sensory Function When Using High-Frequency (10-kHz) Spinal Cord Stimulation in Individuals With Painful Diabetic Neuropathy: A Multicenter Randomized Controlled Trial (PDN-Sensory).
The multicenter randomized controlled PDN-Sensory trial evaluated 10-kHz spinal cord stimulation (SCS) plus conventional medical management (CMM) versus CMM alone in people with painful diabetic neuropathy.
Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.
This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.
Semaglutide modulates explore/exploit decision-making in major depressive disorder: A randomized clinical trial.
This secondary analysis of a randomized clinical trial examined whether semaglutide affected explore/exploit decision-making in 72 participants with major depressive disorder (MDD).
When Insulin Must Wait: The Role of Renal Replacement Therapy in Refractory Hypokalemia During Severe Diabetic Ketoacidosis.
A 37-year-old man presented with abdominal pain, progressive dyspnea, drowsiness, and Kussmaul respirations. Testing showed severe diabetic ketoacidosis (DKA), acute kidney injury, and severe hypokalemia.
Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review.
A 4-year-old girl presented with recurrent hypertension, polycythemia and renal hilar masses. Imaging, biochemical testing and genetic analysis of paraffin-embedded tissue confirmed Pacak-Zhuang syndrome with a somatic…
Daily consumption of unsalted, skin-roasted peanuts beneficially affects regional brain insulin responsiveness in older adults: results of a longer-term randomized controlled trial.
This randomized, single-blind, controlled crossover trial examined whether peanut intake altered brain insulin responsiveness in 31 older adults (67 ± 4 years).
Whole egg consumption effects on vitamin D and carotenoids bioavailability in pre- and post-menopausal females: a randomized crossover controlled feeding trial.
This randomized crossover controlled-feeding trial examined whether whole eggs eaten with a cooked vegetable meal altered postprandial nutrient absorption in 9 pre-menopausal and 8 post-menopausal females.
Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes.
This study investigated whether mitochondrial Rho GTPase 1 (Miro1) contributes to skeletal muscle insulin resistance in type 2 diabetes (T2D).
Periconceptional and early-pregnancy exposure to SGLT2 inhibitors and congenital malformations: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed observational cohort evidence on preconception or early-pregnancy SGLT2 inhibitor exposure among women with type 2 diabetes.
Approach to the patient with APS-1/APECED.
This article presents five cases of autoimmune polyendocrine syndrome type 1 (APS-1/APECED), a disorder caused by impaired immune tolerance and typically associated with biallelic AIRE variants.
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