Calorie-Restricted DASH, Carbohydrate-Restricted, and Low-Purine Diets for Weight Loss and Urate Control in Men With Overweight or Obesity and Hyperuricemia: A Randomized Trial.
Shuang Liu, Le Yan, Yueye Huang et al.
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In 30 seconds
This 12-week, open-label, active-comparator randomized trial compared calorie-restricted carbohydrate-restricted, DASH, and low-purine balanced diets in 102 men with overweight or obesity and hyperuricemia. Among the 85 participants who completed follow-up, mean weight loss was 8.47 kg (9.3%), with no difference between diets (P = 0.99). Adjusted serum urate changes were -0.89 mg/dL, -0.79 mg/dL, and -0.50 mg/dL, respectively, also without a significant between-group difference (P = 0.48). DASH adherence was higher and was associated with less soft lean mass loss than the carbohydrate-restricted diet.
Key findings
- Mean weight loss was 8.47 kg (9.3%) at week 12, with no between-group difference (P = 0.99).
- Adjusted serum urate changes were -0.89 mg/dL with the carbohydrate-restricted diet, -0.79 mg/dL with DASH, and -0.50 mg/dL with the low-purine balanced diet (P = 0.48 between groups).
- Capillary monitoring showed a transient week 1 urate increase coinciding with the early peak in gout flares.
- DASH adherence was higher than with the other diets and was associated with less soft lean mass loss than the carbohydrate-restricted diet.
Why it matters
The findings suggest that, in men with overweight or obesity and hyperuricemia, calorie restriction can produce substantial short-term weight loss, but the tested dietary patterns did not differ significantly in serum urate reduction. The early urate rise and coincident flare peak also draw attention to possible short-term instability when structured weight loss begins.
What to keep in mind
Follow-up was limited to 12 weeks, and 17 of 102 randomized participants did not complete follow-up. The trial was open-label and included men only.