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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchRheumatology

Effects of exercise on muscle strength and characteristics in rheumatic diseases and sarcopenia: Protocol for the Care for Muscle (C4M) Study.

PLoS OneSep 9, 2026

The C4M Study is a randomized controlled trial investigating the effects of strength versus endurance exercise on muscle strength and characteristics in patients with rheumatoid arthritis (RA), osteoarthritis (OA), and…

Why it matters

Understanding the differential effects of exercise types on muscle strength in rheumatic diseases and sarcopenia can inform personalized rehabilitation strategies, potentially improving patient outcomes and quality of…

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Also worth knowing

Clinical ResearchRheumatology

Diagnostic Performance of Machine Learning for Systemic Lupus Erythematosus: Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the diagnostic performance of machine learning (ML) and deep learning (DL) models for systemic lupus erythematosus (SLE) classification, lupus nephritis (LN) diagnosis…

J Med Internet ResSep 4, 2026Open accessRead summary
Clinical ResearchRheumatology

Clinical and autoantibody associations with malignancy in systemic sclerosis: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated factors linked to malignancy in 27,624 patients with systemic sclerosis (SSc).

Rheumatology (Oxford)Sep 1, 2026Read summary
Clinical ResearchRheumatology

Classification performance of the 2023 ACR/EULAR antiphospholipid syndrome criteria: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the classification performance of the 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) across 24 studies.

Rheumatology (Oxford)Sep 1, 2026Read summary
Clinical ResearchRheumatology

Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial.

This randomized controlled trial evaluated the effects of yoga versus combined exercise on pain, balance, mobility, fatigue, depression, and quality of life in 74 females with rheumatoid arthritis in remission.

Musculoskeletal CareSep 1, 2026Open accessRead summary
Clinical ResearchRheumatology

Efficacy and Safety of Ultra-Low Starting Dose Febuxostat Titration in Male Patients With Primary Gout.

This randomized controlled trial evaluated the efficacy and safety of initiating febuxostat at an ultra-low dose of 10 mg/day versus the standard 20 mg/day in 120 male patients with primary gout.

Int J Rheum DisSep 1, 2026Read summary
Clinical ResearchRheumatology

Inebilizumab treatment in Japanese patients with IgG4-related disease: A subgroup analysis of a randomized, double-blind, placebo-controlled, phase 3 trial (MITIGATE).

This subgroup analysis of the MITIGATE study evaluated the efficacy and safety of inebilizumab in 27 Japanese patients with IgG4-related disease.

Mod RheumatolAug 31, 2026Read summary
Clinical ResearchRheumatology

Upadacitinib monotherapy versus methotrexate monotherapy in methotrexate-naïve Japanese patients with rheumatoid arthritis: Long-term efficacy and safety through 5 years in the SELECT-EARLY study.

This Phase III randomized controlled trial evaluated the long-term efficacy and safety of upadacitinib monotherapy versus methotrexate in methotrexate-naïve Japanese patients with rheumatoid arthritis over 5 years.

Mod RheumatolAug 31, 2026Read summary
Clinical ResearchRheumatology

SPOT: An Early Detection Tool for Predicting Pain Trajectories Following Intra-Articular Injections.

This randomized controlled trial aimed to identify 12-month pain trajectories in knee osteoarthritis (KOA) patients post-injection and develop a predictive model using patient-reported pain scores.

J Orthop ResSep 1, 2026Open accessRead summary
Case ReportRheumatology

Systemic sclerosis presenting as recurrent pericardial effusion despite repeatedly negative multiplex antinuclear antibody results.

A woman in her 70s presented multiple times with recurrent pericardial effusions, despite negative multiplex antinuclear antibody (ANA) results.

BMJ Case RepSep 7, 2026Read case
Clinical ResearchRheumatology

Systematic Literature Review Informing Paediatric Rheumatology European Society/Childhood Arthritis and Rheumatology Research Alliance-Endorsed Recommendations for the Treat-to-Target Strategy in Juvenile Dermatomyositis.

This systematic literature review aimed to evaluate evidence supporting the treat-to-target (T2T) strategy in managing juvenile dermatomyositis (JDM).

J RheumatolSep 1, 2026Read summary
Clinical ResearchRheumatology

The utility of 18F-fluorodeoxyglucose PET/computed tomography in relapsing polychondritis: a systematic review and meta-analysis.

This systematic review and meta-analysis evaluated the utility of 18F-fluorodeoxyglucose PET/CT in relapsing polychondritis, analyzing data from three studies involving 97 patients.

Nucl Med CommunSep 8, 2026Read summary

Showing 12 of 23 publications that cleared our clinical screen in the last 14 days.

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