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2000 articles
October 202624
Perineural versus intravenous dexmedetomidine as an adjuvant for ilioinguinal/iliohypogastric nerve block in open inguinal hernia repair: a randomised controlled trial.
This single-centre, triple-blind randomised controlled trial compared perineural, intravenous and placebo dexmedetomidine as adjuncts to an ilioinguinal/iliohypogastric nerve block in 90 adults undergoing elective open…
Robotic selective thoracic sympathectomy for hyperhidrosis: refined technique and anatomical variation.
Primary hyperhidrosis substantially impairs quality of life. Conventional sympathectomy risks compensatory hyperhidrosis through trunk disruption, whilst selective sympathectomy preserves the trunk while dividing…
Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes-An umbrella review of systematic reviews and meta-analyses.
This umbrella review of 21 systematic reviews, including meta-analyses, assessed composite diet and lifestyle quality in relation to endometrial cancer (EC) risk and survivorship outcomes.
Case Report: Veno-Arteriovenous Extracorporeal Membrane Oxygenation for Management of Pheochromocytoma-Induced Cardiac Arrest in a Post-Partum Patient.
A 34-year-old woman, two days postpartum, was admitted to intensive care with hypertensive crisis and respiratory failure. CT showed an 18-cm left adrenal mass suspicious for pheochromocytoma.
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury.
This multicenter, open-label, randomized noninferiority trial compared intermittent hemodialysis with continuous renal-replacement therapy as initial treatment in critically ill adults with acute kidney injury and…
A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined acute changes in circulating tryptophan (TRP) and kynurenine-pathway metabolites after a single exercise session.
An Internet-Based Cognitive-Behavioral Program, With Telephone Support, Improves Pain, Disability and Emotional Well-Being in Adults With Chronic Pain: Randomized Controlled Trial of the Pain Course With 2-Year Follow-Up.
This randomised controlled trial evaluated an internet-delivered, cognitive-behavioral Pain Course with clinician support in adults with chronic pain living in Ireland.
Characterizing vaginal misoprostol induction in individuals with and without severe obesity.
This secondary analysis of the vaginal misoprostol arm of a cluster-randomized trial compared term inductions in individuals with BMI < 40 versus ≥ 40 kg/m².
Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial.
This single-blinded randomized controlled trial compared high-intensity laser therapy (HILT), low-level laser therapy (LLLT), and sham laser, each alongside physiotherapy, in 69 people with electromyography- and…
Severe growth retardation in Dent disease: a case report of a novel OCRL variant.
A 12-year-old boy with marked short stature and poor weight gain had low-molecular-weight proteinuria, haematuria, hypercalciuria and bilateral nephrocalcinosis, with normal renal function and no relevant family…
Antibiotic-Loaded Hydrogel, Calcium Bead, and Cement in Periprosthetic Joint Infection Following Hip-Knee Arthroplasty: A Systematic Review and Meta-Analysis of Commercially Available Products.
This systematic review and meta-analysis compared defensive antibacterial coating (DAC), calcium sulfate beads, and antibiotic-loaded bone cement for preventing or managing periprosthetic joint infection after total hip…
Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer's disease.
This study evaluated VG-3927, an oral, CNS-penetrant small-molecule TREM2 agonist, using preclinical models and a first-in-human randomized, double-blind, placebo-controlled phase 1 trial.
Early extracranial dissemination with prolonged survival in IDH-wildtype glioblastoma: case study and comprehensive literature review.
A 65-year-old woman with IDH-wildtype, MGMT-methylated glioblastoma presented with seizures, right hemiplegia, and expressive aphasia.
Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between body composition and outcomes in patients with hepatocellular carcinoma (HCC), across curative, locoregional, systemic, and mixed treatment…
Cortisol and cognition in psychotic disorders: A systematic review and multi-level meta-analysis.
This systematic review and three-level meta-analysis examined associations between cortisol and cognition in people with psychotic disorders.
Ramadan Fasting in Chronic Heart Failure: A Systematic Review.
This systematic review assessed clinical studies of Ramadan fasting in people with chronic heart failure. Searches of PubMed, Scopus, and Web of Science identified seven eligible studies from 137 records; most were…
Routine versus postoperative CRP/CT guided selective diverting ileostomy after laparoscopic low anterior resection for rectal cancer: a comparative randomized controlled trial.
This randomized controlled trial compared postoperative CRP/CT-guided selective diversion with routine diverting ileostomy in 200 patients with stage II or III middle or lower rectal cancer undergoing laparoscopic low…
Volumetric discordance between ¹⁸F-FET-PET/MRI and MRI-based radiotherapy target volumes in high-grade glioma: a prospective pilot study (FETSMaRT).
This prospective pilot study enrolled 30 patients with WHO grade 3 or 4 high-grade glioma receiving postoperative radiotherapy.
Modified LIFT via a Lateral Approach Versus Standard LIFT for Transsphincteric Anal Fistula: A Prospective Randomized Study.
This single-center prospective randomized study compared modified ligation of the intersphincteric fistula tract (LIFT) via a lateral approach with standard LIFT in adults with MRI-confirmed transsphincteric anal…
Endoscopic secondary chordae transfer and edge-to-edge repair for the treatment of asymmetric anterior leaflet prolapse.
A 59-year-old patient with Barlow’s disease presented with severe mitral regurgitation from asymmetric anterior leaflet prolapse.
Multiple-Staged Versus Single-Stage Surgical Excision for the Reconstruction of Congenital Melanocytic Nevi: A Meta-Analysis of Efficacy and Safety.
This meta-analysis compared multiple-staged with single-stage excision and reconstruction for congenital melanocytic nevi (CMN). It pooled seven retrospective cohort or clinical controlled studies involving 578 patients.
Anxiety in patients with cancer and emergency department use: a systematic review.
This systematic review examined whether anxiety is associated with subsequent emergency department (ED) use among adults with cancer.
Immune biomarkers of response and resistance to ipilimumab and nivolumab in metastatic castration-resistant prostate cancer.
The multicenter phase II AMADEUS prostate expansion cohort evaluated escalating ipilimumab doses with nivolumab in 32 patients with metastatic castration-resistant prostate cancer, assessing disease control, tumoral CD8…
Patient-reported and caregiver-reported outcomes in refractory ascites secondary to cirrhosis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined patient- and caregiver-reported outcomes in refractory ascites (RA) secondary to advanced chronic liver disease.
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