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2000 articles
October 202624
Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis compared clinical, metabolic, and hormonal profiles in obese and lean women with polycystic ovary syndrome (PCOS).
EORTC QLQ-C30 symptom components and their functional correlates during adjuvant chemotherapy for early breast cancer: a multivariate analysis. Data from GEICAM/2003-02 study.
This multivariate analysis of data from a multicentre phase III randomised trial examined changes in EORTC QLQ-C30 symptoms and their relationships with functioning among 820 patients with early breast cancer receiving…
Exploring the Neural Mechanisms of Acupuncture Stimulation in Autism Spectrum Disorder: Protocol for a Randomized, Sham-Controlled, Multimodal Neuroimaging Trial.
This protocol describes a randomized, sham-controlled, stratified 2×2 trial designed to examine brain differences associated with autism spectrum disorder (ASD) and the acute neural response to acupuncture.
Robotic systems in cranial surgery: a systematic review of accuracy, clinical outcomes, and adverse events.
This systematic review examined robotic systems used in cranial neurosurgical procedures and their reported accuracy, clinical outcomes, and adverse events.
Genetic Variants in Intracranial Atherosclerotic Disease: A Systematic Review and Targeted Meta-Analysis Highlighting the RNF213 rs112735431.
This systematic review and targeted meta-analysis examined genetic variants associated with intracranial atherosclerotic disease (ICAD) in human studies identified through September 2025.
Omega-6 Polyunsaturated Fatty Acids and Peripheral Artery Disease: An Individual Participant-Level Analysis of 9 International Prospective Studies.
This multicohort individual participant-level analysis and meta-analysis examined baseline omega-6 polyunsaturated fatty acids and incident peripheral artery disease (PAD) among 137,704 participants without clinical PAD…
Incidence and Influencing Factors of Pain Crisis in Cancer Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the incidence of pain crisis and associated factors among people with cancer. Seven studies including 1865 patients were analysed; the pooled incidence was 37%.
Pilot Randomized Trial of 2 Food Purchasing Interventions in Individuals With Hypertension in New Orleans: An American Heart Association Food Is Medicine Initiative.
This randomized pilot trial compared online and in-store food vouchers among 98 people with uncontrolled hypertension in New Orleans.
Impact of Evolocumab on LDL-Cholesterol and Cardiovascular Outcomes in Patients With Established CVD: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled randomised controlled trials of evolocumab in adults with established cardiovascular disease.
Effect of web-based education on NIV-related side effects and insomnia severity in COPD patients using home NIV: a randomized controlled trial.
This randomized controlled trial evaluated web-based education about NIV-related side effects and insomnia management in 75 patients with COPD using home noninvasive ventilation.
Tirzepatide-induced pneumatosis intestinalis: a rare but clinically significant gastrointestinal adverse effect.
A 55-year-old man with obesity, type 2 diabetes, hypertension, and obstructive sleep apnea presented with abdominal pain, constipation, and anal fissures while receiving tirzepatide for approximately 1 year; he had lost…
Plasma Glutamine and Glutamate in Relation to Clinical Outcomes After Ischemic Stroke: A Multicenter Prospective Study.
This secondary analysis of the multicenter CATIS study examined plasma glutamine (Gln), glutamate (Glu), and their ratio (GGR) in 3499 patients with ischemic stroke.
Effects of gliflozins on bone health of patients with chronic kidney disease: a systematic review.
This systematic review assessed skeletal safety and bone-related metabolic outcomes with sodium-glucose co-transporter-2 inhibitors (SGLT2i) in people with chronic kidney disease, drawing on randomised trials and…
Exercise modality and planned weekly exercise exposure for motor outcomes in Parkinson's disease: a systematic review, Bayesian network meta-analysis, and meta-regression.
This systematic review and Bayesian network meta-analysis synthesized 173 randomized trials of exercise in people with Parkinson’s disease, assessing motor symptoms, balance, walking speed, and Timed Up and Go (TUG).
Body Mass Index, Valsartan, and Myocardial Remodeling in Early-Stage Hypertrophic Cardiomyopathy: A Secondary Analysis of the Randomized VANISH Trial.
This post hoc analysis of the randomized, multicenter VANISH trial examined BMI and cardiac remodeling in participants with early-stage hypertrophic cardiomyopathy. Of 171 participants, 52% had elevated BMI.
Effects of anti-inflammatory dietary education on sleep disturbances among patients with breast cancer undergoing chemotherapy: A randomized controlled trial.
This randomized controlled trial assessed whether anti-inflammatory dietary education could improve sleep and related outcomes in 132 patients with breast cancer, sleep disturbances, and ongoing chemotherapy.
Bridging evidence gaps in opioid-sparing postoperative pain control for percutaneous nephrolithotomy: a network meta-analysis identifying optimal strategies.
This systematic review and Bayesian network meta-analysis compared postoperative analgesic strategies in adults undergoing percutaneous nephrolithotomy (PCNL), using randomised controlled trials that assessed pain.
The effect of a stress ball on pain, anxiety, satisfaction, and treatment continuation during extracorporeal shock wave lithotripsy: a randomized controlled trial.
This prospective, two-arm randomized controlled trial assessed whether using a stress ball during extracorporeal shock wave lithotripsy (ESWL) affected pain, anxiety, satisfaction, and continuation among 50 patients…
The effect of cognitive behavioral therapy for sleep and glycemic outcomes in people with diabetes: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled 10 randomised controlled trials involving 2,827 people with diabetes from four countries to assess cognitive behavioral therapy (CBT) for sleep and glycemic outcomes.
Bionic sleep therapy combined with multimodal management for chronic insomnia with alcohol withdrawal-related symptoms: A case report.
A 71-year-old man with more than 15 years of insomnia used 100 to 200 mL of Chinese baijiu nightly to sleep. Attempts to stop drinking brought worsening insomnia, restlessness, palpitations, sweating, and intense…
Outcomes of sequential keratoplasty for bilateral gelatinous drop-like corneal dystrophy: A case report.
A 21-year-old woman of Yemeni ancestry with long-standing bilateral visual impairment, progressive left-eye decline, foreign-body sensation, and a positive family history had previously undergone right penetrating…
Staged bilateral reverse sural artery flap reconstruction for severe frostbite of both feet in a patient with schizophrenia: A case report.
A 25-year-old man with acute psychosis walked barefoot in subzero conditions for about 12 hours, sustaining deep frostbite of both heels and multiple toes.
Efficacy of Tecovirimat for the Treatment of Mpox Virus Infection in Humans: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed tecovirimat efficacy and safety in patients with laboratory-confirmed mpox, comparing it with placebo or standard care in randomised controlled trials.
Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.
This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…
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