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2000 articles
October 202624
RETINAL VASCULITIS ASSOCIATED WITH TYPE M2 ANTIMITOCHONDRIAL ANTIBODIES.
A 35-year-old woman presented with photopsia but no reduction in visual acuity. Examination showed bilateral retinal vasculitis, predominantly venous and more extensive in the left eye, involving both central and…
Vascular health after quitting smoking or switching to e-cigarette use: a systematic review of prospective studies with GRADE assessment.
This systematic review assessed prospective evidence on vascular function after smoking cessation or switching to exclusive e-cigarette use among adult smokers.
Changes in gait function associated with cerebral small vessel disease-related cognitive impairment during dual-task walking: a systematic review and meta-analysis.
This systematic review and meta-analysis examined whether dual-task (DT) gait measures distinguish people with cerebral small vessel disease-related cognitive impairment (CSVD-CI) from cognitively unimpaired controls…
A NETwork meta-analysis with COST-effectiveness evaluation of pharmacological treatments for heart failure with reduced ejection fraction: NET-COST-HFrEF.
This network meta-analysis of 47 randomized controlled trials involving 75,978 patients with heart failure with reduced ejection fraction assessed guideline-directed drug combinations and their cost-effectiveness.
A Randomized, Double-Blind, Placebo-Controlled Study of the PD-1 Inhibitor Cetrelimab in Chronic Hepatitis B.
This randomized, double-blind, placebo-controlled study assessed the safety, activity and pharmacokinetics of a single low dose of the PD-1 inhibitor cetrelimab in adults with chronic hepatitis B virologically…
Long-term impact of aficamten on patient-reported outcome measures in obstructive hypertrophic cardiomyopathy: results from FOREST-HCM.
This open-label extension study assessed longer-term patient-reported outcomes with aficamten in people with obstructive hypertrophic cardiomyopathy who had completed an aficamten trial.
Comparison of sterile silicone studs and scalp infiltration with lignocaine for the attenuation of the hemodynamic and stress response to skull pin insertion during craniotomy in pediatric neurosurgical patients: a randomized controlled trial : Sterile silicone studs versus lignocaine infiltration for skull pin insertion.
This randomized controlled trial compared sterile silicone studs (SSS) with lignocaine infiltration for skull pin insertion in 64 children aged 12 years or younger undergoing neurosurgery.
Neck-Specific Exercises With Internet Support Versus Standard Neck-Specific Exercise for the Treatment of Chronic Whiplash-Associated Disorders: Cost-Effectiveness Analysis.
This prospective, multicenter randomized controlled trial compared a 3-month internet-supported neck-specific exercise program plus four physiotherapy visits (NSEIT) with clinic-based neck-specific exercise twice weekly…
Pars plana vitrectomy with silicone oil versus pars plana vitrectomy alone for postoperative endophthalmitis: A randomized controlled trial.
This prospective randomized controlled trial compared pars plana vitrectomy (PPV) with 1000-cSt silicone oil (SO) tamponade against PPV alone in 40 eyes with severe post-phacoemulsification endophthalmitis unresponsive…
SUCCESSFUL MANAGEMENT OF A GIANT MACULAR HOLE IN ALPORT SYNDROME USING AUTOLOGOUS RETINAL TRANSLATION AS AN INITIAL PROCEDURE.
A 30-year-old woman with Alport syndrome had bilateral anterior lenticonus and a giant full-thickness macular hole in her right eye, measuring 1,791 μm.
IDIOPATHIC ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY: A 5-YEAR FOLLOW-UP.
A patient with idiopathic acute exudative polymorphic vitelliform maculopathy had 20/20 visual acuity in both eyes. Examination showed symmetrical multifocal serous retinal detachments and foveal vitelliform lesions…
MULTIMODAL IMAGING OF BENIGN LOBULAR INNER NUCLEAR LAYER PROLIFERATIONS.
A 10-year-old boy was evaluated for multiple whitish intraretinal lesions and widespread pigmented spots. Examination showed bilateral lesions at the posterior pole and midperiphery, alongside extensive grouped…
An Elusive Diagnosis of Strongyloides Infection Masquerading as Daptomycin-Induced Eosinophilic Pneumonitis.
A middle-aged man with alcoholic cirrhosis developed peripheral eosinophilia, bilateral pulmonary nodules, migratory consolidative opacities, and pleural effusions while receiving daptomycin for polymicrobial…
Performance of prediction models for incident heart failure and heart failure hospitalization in individuals with type 2 diabetes: a systematic review and meta-analysis.
This systematic review and Bayesian meta-analysis assessed multivariable models predicting incident heart failure (HF) or HF hospitalization (HFH) in people with type 2 diabetes.
Catheter ablation in end-stage heart failure with atrial fibrillation: an hierarchical endpoint analysis of the CASTLE-HTx trial.
This ancillary hierarchical endpoint analysis of the multicentre randomized CASTLE-HTx trial compared catheter ablation plus guideline-directed medical therapy (GDMT) with medical therapy alone in 194 patients with…
A missense variant in LAMB3 underlies variable expressivity in familial tooth agenesis and microdontia.
A three-generation family presented with non-syndromic dental anomalies, including missing teeth (oligodontia), microdontia and delayed eruption.
HHV-6 Encephalitis Presenting With Severe SIADH and CO₂ Narcosis in Non-Transplant Smoldering Adult T-Cell Leukemia/Lymphoma.
A 55-year-old woman with smoldering adult T-cell leukemia/lymphoma (ATLL), treated with systemic corticosteroids for suspected HTLV-1-associated uveitis, was admitted with pulmonary infection.
Peritoneal Tuberculosis and Chronic Myeloid Leukaemia: A Case of Hickam's Dictum.
A 34-year-old man presented with persistent fever, ascites, thrombocytosis and clinical deterioration despite broad-spectrum therapy.
Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.
This single-center randomized controlled trial compared postoperative abstinence with standardized red wine intake in habitual wine drinkers undergoing elective urological surgery.
Impact of Intermittent Preventive Treatment for Malaria in Pregnancy With Sulfadoxine-Pyrimethamine, Dihydroartemisinin-Piperaquine, and Their Combination on Infant Outcomes: A Randomized Controlled Trial.
This double-blind randomized controlled trial compared infant malaria and growth outcomes after maternal intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine…
A CASE OF CHOROIDAL NEOVASCULAR MEMBRANE IN ENHANCED S-CONE SYNDROME TREATED WITH AFLIBERCEPT.
An 18-year-old male presented after six days of declining vision in his left eye. Testing showed foveomacular schisis in the right eye and active choroidal neovascularization in the left; further evaluation confirmed…
Impact of Chatbot-Based Cognitive Training on Cognitive Function and White Matter Integrity in Cognitively Unimpaired Older Adults: Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated chatbot-based cognitive training in 72 cognitively unimpaired older adults.
Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responses.
This phase 1 controlled human challenge trial enrolled 45 healthy adults to examine how preexisting immunity shapes responses to heterotypic dengue virus challenge.
B cell subsets are associated with durable responses in distinct cancer types after immune checkpoint inhibition.
This study examined B-cell responses and outcomes after immune checkpoint inhibition, combining a prospective randomized phase 2 trial of 106 patients with single-cell profiling of intratumoral B cells from 152 patients…
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