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1022 articles
September 202624
A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels.
Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy.
Anxiety disorders, PTSD, and risk of first-ever stroke: A meta-analysis of 11 million participants.
This meta-analysis pooled 23 longitudinal cohort studies involving 11,181,338 participants to assess whether anxiety disorders, obsessive-compulsive disorder (OCD), and PTSD were associated with first-ever stroke.
The post-acute effects of COVID-19 are not associated with robust long-term regional or global brain volumetric changes: A Bayesian meta-analytic evidence.
This Bayesian meta-analysis assessed whether MRI studies show reproducible long-term brain-volume differences after COVID-19.
Mixed-amphetamine salts, extended release for cognitive impairment in persons with MS, a randomized controlled trial.
This double-blind, placebo-controlled, multicentre randomised trial assessed extended-release mixed-amphetamine salts (MAS-XR) for cognitive impairment in people with multiple sclerosis who had impaired Symbol Digit…
Stroke secondary to cancer-associated coagulopathy: a systematic review.
This systematic review examined cancer-associated coagulopathy (CAC) as a cause of ischemic stroke in cancer patients, analyzing 82 studies.
What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review.
This systematic review examines the phenotypic characteristics of iPSC-derived motor neurons from ALS patients with TARDBP mutations.
Encephalitic rabies following cat bites: two cases in northern Uganda.
Two Ugandan males presented with rapidly progressive encephalitic rabies following cat bites. Both cases exhibited typical clinical features of rabies, leading to a swift decline in neurological function and ultimately…
Oxygen desaturation in patients with functional seizures: pitfalls for the unwary.
A patient with recurrent functional seizures exhibited documented oxygen desaturation, leading to extensive cardiopulmonary investigations and repeat video-electroencephalogram evaluation.
Scalp necrosis and visual loss in giant cell arteritis: the importance of recognising atypical cutaneous clues.
A 70-year-old woman presented with left hemifacial pain and bilateral forehead skin plaques, initially diagnosed as shingles.
Arthrogryposis as a neuromuscular phenotype: lessons from PIEZO2 loss-of-function.
A 43-year-old woman presented with congenital clubfoot, progressive scoliosis, and distal joint contractures. Neurological examination revealed pure sensory findings, global areflexia, severe sensory ataxia, and a…
Hereditary transthyretin amyloidosis with hand weakness and bulbar involvement.
A 76-year-old man presented with progressive motor weakness, bulbar symptoms, and hand muscle atrophy, initially misdiagnosed as motor neurone disease.
Aphasic status epilepticus complicating hyperosmolar hyperglycaemic state.
A 66-year-old man with type 2 diabetes presented with progressive speech decline and impaired coordination after a fall. EEG confirmed non-convulsive status epilepticus, and MRI revealed transient left temporal changes…
Bilateral facial palsy due to Melkersson-Rosenthal syndrome.
A 29-year-old woman presented with bilateral facial nerve palsy of unknown origin despite extensive testing. After further evaluation, she developed upper lip swelling, which led to the diagnosis of Melkersson-Rosenthal…
Extraosseous Ewing sarcoma of the common fibular nerve.
A 64-year-old woman presented with progressive weakness of the left foot, leading to the diagnosis of an intraneural extraosseous Ewing sarcoma of the common fibular nerve.
Coma from severe spontaneous intracranial hypotension due to a CSF-venous fistula.
A patient presented in a coma due to severe spontaneous intracranial hypotension (SIH) caused by a spinal CSF-venous fistula. The condition led to significant brain sagging, compromising brainstem function.
From Neurophysiological Mechanisms to Rehabilitation After Botulinum Toxin Type A in Post-Stroke Spasticity.
This systematic review and meta-analysis examined the neurophysiological mechanisms of botulinum toxin type A (BoNT-A) in treating post-stroke spasticity (PSS) across 39 studies with 760 patients.
Pure Motor Axonal Neuropathy Associated with Sjögren's Syndrome: A Rare Case Report.
A 47-year-old man with a history of sicca symptoms presented with progressive, asymmetric motor weakness in all four limbs, without sensory involvement.
The Role of the Antidepressants in Managing Chemotherapy-Induced Neuropathic Pain: A Systematic Review.
This systematic review assessed the efficacy and safety of antidepressants, particularly duloxetine and amitriptyline, in managing chemotherapy-induced peripheral neuropathy (CIPN) pain in adults.
Psychiatric manifestation of neurosarcoidosis: a systematic review with pooled descriptive analysis of case reports and case series.
Neurosarcoidosis is a rare inflammatory disease with a heterogeneous presentation. Psychiatric manifestations may precede neurological involvement, but their prevalence, diagnostic pattern, and treatment outcomes remain…
Safety and efficacy of repeated intravenous thrombolysis within 3 months for acute ischemic stroke: a systematic review and individual-patient data meta-analysis.
This systematic review and individual-patient data meta-analysis evaluated the safety and efficacy of repeated intravenous thrombolysis (RIVT) for acute ischemic stroke (AIS) within 90 days of a previous treatment.
Expanding the adult spectrum of TUBB4A disease: a spasticity-tremor phenotype with network imaging correlates.
TUBB4A mutations cause a spectrum of neurological disorders, but adult-onset hereditary spastic paraplegia is rarely described.
Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles as a cell-free approach in autism spectrum disorder: A systematic review and meta-analysis of preclinical studies.
This systematic review and meta-analysis evaluated the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in preclinical models of Autism Spectrum Disorder (ASD).
One target, two evidence streams: Rituximab versus ocrelizumab in relapsing multiple sclerosis: A design-stratified systematic review, meta-analysis, and concordance assessment.
This design-stratified systematic review and meta-analysis compared rituximab with ocrelizumab in adults with relapsing multiple sclerosis, synthesizing randomized and longitudinal observational evidence separately.
Neuroradiologic Findings in Patients With S CN2A Disease: A Systematic Review and Retrospective Multicenter Cohort Study.
This systematic review and retrospective multicenter cohort study examined neuroradiologic findings in 354 patients with SCN2A disease.
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