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1821 articles
September 202624
A rare ATM variant in a Colombian family with chorea-ataxia syndrome: implications for an early diagnosis.
A 39-year-old man presented with progressive ataxia, chorea, and telangiectasias, alongside two siblings with similar symptoms. Genetic testing revealed compound heterozygous variants in the ATM gene.
Osteosarcoma of the Maxilla: Rare Contralateral Cervical Lymph Node Metastasis.
A patient with osteosarcoma of the maxilla presented with contralateral cervical lymph node metastasis following surgical intervention.
Giant Well-Differentiated Liposarcoma of the Spermatic Cord Associated With Inguinal Hernia: Clinical Insights From a Case Report.
An 87-year-old man presented with a progressively enlarging, painless mass in the left inguinoscrotal region, which impaired mobility.
Expanded antigen-specific donor regulatory T cells for GVHD prevention.
This phase 1 clinical trial evaluated the safety and preliminary efficacy of expanded minor histocompatibility antigen (mHAg)-specific donor regulatory T cells (Treg) for preventing graft-versus-host disease (GVHD) in…
Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.
This phase II multicenter trial evaluated the efficacy of venetoclax combined with pediatric-inspired chemotherapy in 167 adolescents and adults with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic…
Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study.
This population pharmacokinetic analysis evaluated pirtobrutinib, a non-covalent BTK inhibitor, in 595 patients with hematological malignancies from the Phase 1/2 BRUIN study.
Association of androgen deprivation therapy and acute kidney injury in patients with prostate cancer: a systematic review and meta-analysis of 72,980 patients.
This systematic review and meta-analysis evaluated the association between androgen deprivation therapy (ADT) and acute kidney injury (AKI) in 72,980 prostate cancer patients.
Structured exercise interventions and survival outcomes in patients with cancer: systematic review and meta-analysis of randomised controlled trials.
This systematic review and meta-analysis evaluated the impact of structured exercise interventions on survival outcomes in cancer patients.
Femoral Neck System and Cement Augmentation for Temporizing a Pathologic Hip Fracture in Osteosarcoma: A Case Report.
A 17-year-old boy with primary osteosarcoma presented with a pathologic hip fracture. He underwent cement-augmented internal fixation using a femoral neck system, which facilitated pain management and allowed for the…
18F-FDG PET/CT Manifestations of a Gastrointestinal Stromal Tumor Presenting With Predominant Hepatic and Peritoneal Metastases.
A 70-year-old man presented with abdominal pain. Contrast-enhanced CT demonstrated multiple large space-occupying lesions in the liver.
Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer .
This randomized controlled trial investigated the effects of a traditional Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-cell activation in breast cancer patients undergoing postoperative…
Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications.
This meta-analysis evaluated the prognostic significance of NPC2 expression in tumor tissues from 2,097 cancer patients. The study found that elevated NPC2 expression was significantly associated with worse overall…
Ivonescimab plus chemotherapy as first-line treatment for advanced thymic carcinoma: preliminary results of a phase II trial with biomarker analyses.
This phase II trial evaluated ivonescimab combined with chemotherapy in seven patients with advanced thymic carcinoma. The study found a promising objective response rate (ORR) of 85.7% and a disease control rate (DCR)…
TACE combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China: a cost-effectiveness and budget impact analysis.
This study evaluated the clinical efficacy and cost-effectiveness of transarterial chemoembolisation (TACE) combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China.
Management of immune-related cutaneous adverse events associated with immune checkpoint inhibitors in patients with cancer: an evidence summary.
This systematic review synthesizes evidence on managing immune-related cutaneous adverse events (ircAEs) in cancer patients receiving immune checkpoint inhibitors (ICIs).
Effectiveness and Safety of Colorectal Cancer Screening Via Fecal Occult Blood Testing: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the effectiveness of colorectal cancer screening via fecal occult blood tests in adults aged 45-75.
Acceptance and perceived efficacy of intraoral versus extraoral photobiomodulation for oral mucositis prevention in pediatric patients.
This randomized controlled trial evaluated the acceptance and perceived efficacy of intraoral (IO) versus extraoral (EO) photobiomodulation therapy for preventing oral mucositis in 32 pediatric oncology patients.
A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer.
This phase 2 randomized controlled trial assessed the pharmacokinetics, pharmacodynamics, efficacy, and safety of oral netupitant combined with oral palonosetron (NEPA) in pediatric patients (< 18 years) undergoing…
Epidermoid Cyst of the Ureter Mimicking Recurrent Urothelial Carcinoma: A Case Report and Brief Literature Review.
A 79-year-old man with a history of high-grade papillary urothelial carcinoma presented with a proximal right ureteral filling defect on CT scan, raising suspicion for tumor recurrence.
Acupuncture for chemotherapy-induced nausea and vomiting: An umbrella review of systematic reviews.
This umbrella review assessed invasive acupuncture for chemotherapy-induced nausea and vomiting (CINV), synthesizing existing systematic reviews and meta-analyses and conducting a renewed meta-analysis of primary…
Reduced oxaliplatin exposure in gastrointestinal cancers: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared reduced oxaliplatin exposure (ROE) with standard-duration oxaliplatin-based therapy in gastrointestinal cancers.
Five-Year Follow-Up of the Phase III ASCOT Trial of Adjuvant S-1 After Resection for Biliary Tract Cancer.
This prespecified five-year follow-up of the multicenter, open-label, randomized phase III ASCOT trial assessed adjuvant S-1 versus observation after resection for biliary tract cancer in 440 patients in Japan.
Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial.
The EVITA trial, a phase 2 randomized controlled trial, evaluated oral vitamin C supplementation in 109 adults with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies.
API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis.
The API-CAT trial showed that reduced-dose apixaban was noninferior to full-dose for preventing recurrent venous thromboembolism in cancer patients.
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