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751 articles
October 202624
Bone phenotype of patients with genetic forms of lipodystrophy: a systematic review of literature.
This systematic review examined bone manifestations in people with genetic lipodystrophies, using human studies identified through searches of PubMed, EMBASE, and the Cochrane Library.
The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.
This systematic review and meta-analysis assessed autoimmune susceptibility in people with Klinefelter syndrome (47,XXY), using studies of autoimmune disease and serological markers.
Retatrutide and lipid and metabolite profiles in participants with obesity with or without type 2 diabetes.
This post hoc exploratory analysis of two randomized, placebo-controlled phase 2 trials examined fasting plasma metabolite and lipid changes with retatrutide in participants with obesity, with or without type 2…
Efficacy and safety of imeglimin hydrochloride for metabolic dysfunction-associated steatotic liver disease with type 2 diabetes: Single-center, single-arm phase 2 (IMELD study).
This single-center, single-arm phase 2 interventional study assessed 24 weeks of imeglimin in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes.
Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.
Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study.
This single-arm phase II study evaluated behavioral weight loss (BWL), with Contrave added for women with prior stage 0 to III breast cancer who lost less than 5% of their weight after two months.
AI-Driven Lifestyle Interventions for Reducing Diabetes Risk: Systematic Review.
This systematic review assessed AI-driven digital lifestyle interventions for people with prediabetes or elevated diabetes risk, including healthy participants in feasibility studies.
Behind the Sella: A Rare Case of Pituicytoma Mimicking a Pituitary Adenoma.
A 48-year-old man presented with symptoms of hypogonadism, headaches, and visual field defects. Testing showed hypogonadotropic hypogonadism and hyperprolactinemia, while MRI revealed a sellar-suprasellar mass initially…
Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and random-effects meta-analysis assessed efficacy and safety of oral enlicitide in adults with hypercholesterolemia.
Vegetarian and Vegan Diets and the Risk of Hip Fracture in Adults: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed hip-fracture risk in adults following vegetarian or vegan diets compared with meat-eaters. Four cohort studies involving 529 672 participants were included.
Severe growth retardation in Dent disease: a case report of a novel OCRL variant.
A 12-year-old boy with marked short stature and poor weight gain had low-molecular-weight proteinuria, haematuria, hypercalciuria and bilateral nephrocalcinosis, with normal renal function and no relevant family…
Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review.
This systematic review synthesised 66 preclinical studies of GLP-1 and GLP-1 receptor mono-agonists in animal models, examining food-, drug- and sexual-related reward.
Effectiveness of a self-management intervention on clinical outcomes among patients with type 2 diabetes at high risk for Diabetic Kidney Disease: A Randomised Controlled Trial.
This prospective, two-arm randomised controlled trial at a tertiary hospital in China evaluated a structured self-management programme in 134 adults with type 2 diabetes classified as at high risk of diabetic kidney…
Effect of injectable platelet rich fibrin augmented with vitamin c compared to injectable platelet rich fibrin alone on healing of necrotic mature single rooted teeth with chronic periapical periodontitis following regenerative endodontic therapy (a randomized controlled trial).
This randomized controlled trial compared injectable platelet-rich fibrin (i-PRF) with and without vitamin C during regenerative endodontic treatment in 28 healthy patients with necrotic mature single-rooted teeth and…
Acromegaly as the Initial Presentation of Multiple Endocrine Neoplasia Type 1: A Case Report.
A 34-year-old woman presented with acromegalic features and hypercalcemia. Testing and MRI showed a recurrent growth hormone–secreting pituitary macroadenoma, while neck imaging identified a parathyroid adenoma.
Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis compared clinical, metabolic, and hormonal profiles in obese and lean women with polycystic ovary syndrome (PCOS).
Impact of Evolocumab on LDL-Cholesterol and Cardiovascular Outcomes in Patients With Established CVD: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled randomised controlled trials of evolocumab in adults with established cardiovascular disease.
Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.
This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…
Chronic postsurgical pain following thyroidectomy: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed chronic postsurgical pain after thyroidectomy, synthesizing 16 studies involving 1538 patients.
The effect of cognitive behavioral therapy for sleep and glycemic outcomes in people with diabetes: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled 10 randomised controlled trials involving 2,827 people with diabetes from four countries to assess cognitive behavioral therapy (CBT) for sleep and glycemic outcomes.
Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review.
This systematic review synthesised qualitative research on self-care among people living with HIV and hypertension or diabetes in low- and middle-income countries.
Oral microbiome alterations in individuals with type 1 diabetes: a systematic review.
This systematic review evaluated associations between glycemic control and oral microbial findings in people with type 1 diabetes (T1DM), distinguishing targeted tests from comprehensive microbiome profiling.
Time-restricted feeding with resistance training is not superior to conventional feeding for body composition and muscle strength: a systematic review and meta-analysis.
This systematic review and meta-analysis examined time-restricted feeding (TRF) versus conventional diets in healthy adults aged 18 or older undertaking resistance training.
Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.
This 16-week, single-arm clinical trial examined changes in ectopic lipids, insulin sensitivity, advanced glycation end products, and beta-cell function in 25 adults with type 2 diabetes following an ad libitum low-fat…
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