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785 articles
October 202624
Three traditional Chinese patent medicines combined with transarterial chemoembolization for primary liver cancer: A systematic review and Bayesian network meta-analysis.
This systematic review and Bayesian network meta-analysis assessed three traditional Chinese patent medicines combined with transarterial chemoembolization (TACE) for primary liver cancer.
Efficacy and safety of imeglimin hydrochloride for metabolic dysfunction-associated steatotic liver disease with type 2 diabetes: Single-center, single-arm phase 2 (IMELD study).
This single-center, single-arm phase 2 interventional study assessed 24 weeks of imeglimin in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes.
Acute colonic variceal bleeding treated with coil-assisted retrograde transvenous obliteration following atezolizumab-bevacizumab therapy for advanced hepatocellular carcinoma: A case report.
A 66-year-old man with alcohol-related cirrhosis and advanced hepatocellular carcinoma developed hematochezia the day after starting atezolizumab plus bevacizumab.
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.
This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.
Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.
This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
A Meta-Analysis on Outcomes of Zanidatamab Plus Chemotherapy in Patients with Advanced HER2-positive Gastroesophageal Adenocarcinoma.
This meta-analysis pooled outcomes from three clinical trials involving 685 patients with advanced HER2-positive gastroesophageal adenocarcinoma treated first-line with zanidatamab plus chemotherapy, with or without…
Safety, Tolerability and Antiviral Activity of GST-HG131 in Chronic Hepatitis B: A Randomized, Double-Blind Phase IIa Study.
This randomized, double-blind, placebo-controlled Phase IIa trial assessed oral GST-HG131 in 45 adults with chronic hepatitis B receiving nucleos(t)ide analogue monotherapy.
Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes-An umbrella review of systematic reviews and meta-analyses.
This umbrella review of 21 systematic reviews, including meta-analyses, assessed composite diet and lifestyle quality in relation to endometrial cancer (EC) risk and survivorship outcomes.
Fecal microbiota transplantation for the treatment of neurogenic rosacea: protocol of a randomized, blinded, placebo-controlled explorer study.
This publication describes the protocol for a single-center, randomized, double-blind, placebo-controlled exploratory trial of fecal microbiota transplantation (FMT) in patients with neurogenic rosacea, a phenotype…
Patient-reported and caregiver-reported outcomes in refractory ascites secondary to cirrhosis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined patient- and caregiver-reported outcomes in refractory ascites (RA) secondary to advanced chronic liver disease.
Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between body composition and outcomes in patients with hepatocellular carcinoma (HCC), across curative, locoregional, systemic, and mixed treatment…
Network Meta-Analysis: Treatments for Acute Alcohol-Associated Hepatitis.
This systematic review and network meta-analysis compared treatments for alcohol-associated hepatitis (AH) using 90-day survival as the primary outcome.
PTCD and Peroral Electronic Cholangioscopy with Holmium Laser Lithotripsy for CBD Stones in a Super-Elderly Patient Post-Billroth II Gastrojejunostomy.
The management of impacted common bile duct stones in patients with prior Billroth II gastrectomy poses unique challenges. Altered gastrointestinal anatomy renders duodenoscope passage and biliary cannulation during…
Multifactorial Contributors to Diagnostic Delay in a High-Risk Patient with Hepatocellular Carcinoma: A Case Report with Clinical Lessons.
A 45-year-old Chinese man with chronic hepatitis B, type 2 diabetes, and a family history of primary liver cancer (PLC) was at high risk but had no regular PLC surveillance for three years.
Tirzepatide-induced pneumatosis intestinalis: a rare but clinically significant gastrointestinal adverse effect.
A 55-year-old man with obesity, type 2 diabetes, hypertension, and obstructive sleep apnea presented with abdominal pain, constipation, and anal fissures while receiving tirzepatide for approximately 1 year; he had lost…
Analysis of a case of immune-related pancreatitis induced by anti-PD-1 antibody therapy for gastric cancer: A case report.
An 82-year-old woman with metastatic gastric cancer developed mild epigastric pain and acid regurgitation, with elevated pancreatic enzymes, on the second day of her fourth cycle of nivolumab plus apatinib.
Metallic versus plastic stents for the management of biliary obstruction: A GRADE-assessed systematic review and meta-analysis.
This GRADE-assessed systematic review and meta-analysis compared metallic with plastic stents for benign or malignant biliary obstruction, including randomized and observational studies.
A Giant Intra-Abdominal Plasmablastic Neoplasm Favoring Lymphoma Mimicking an Exacerbation of Severe Fistulizing Crohn's Disease: A Case Report.
A 44-year-old woman with severe fistulizing Crohn’s disease developed progressive systemic deterioration despite partial intestinal stabilization.
Etrasimod reduces circulating and mucosal inflammatory lymphocyte populations and alters innate immune and non-immune cell signatures in intestinal mucosa: ELEVATE UC phase 3 clinical data.
This analysis of the phase 3 ELEVATE UC randomised trials characterised blood and intestinal mucosal changes in patients with ulcerative colitis treated with etrasimod or placebo.
Tofacitinib 20 vs 30 mg in acute severe ulcerative colitis: a double-blind randomized controlled trial.
This double-blind, pilot randomized controlled trial compared tofacitinib 20 mg/day with 30 mg/day, each given alongside intravenous corticosteroids, in adults with acute severe ulcerative colitis.
Pancreatic Tuberculosis Mimicking Pancreatic Cancer in a Young Immunocompetent Man: A Case Report and Literature Review.
A 34-year-old HIV-seronegative Afghan man had a year of intermittent epigastric pain, nausea, and vomiting. CT showed a 57×30 mm multiloculated hypoattenuating mass in the pancreatic head without biliary dilation; serum…
Finite Versus Indefinite Nucleos(t)ide Analogue Therapy in HBeAg‑Negative Chronic Hepatitis B: Meta‑Analysis of Randomized Trials.
This meta-analysis evaluated the efficacy and safety of finite versus continuous nucleos(t)ide analogue therapy in HBeAg-negative adults with chronic hepatitis B.
Meckel's diverticulum leading to axial torsion and volvulus of the small bowel.
A patient presented with small-bowel obstruction caused by a giant Meckel’s diverticulum measuring 22 cm × 11 cm × 9.8 cm. The diverticulum produced mass effect and was associated with axial torsion and volvulus of the…
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