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427 articles
October 202624
Myeloid neoplasm with PDGFRA rearrangement presenting in blast-phase with basophilia.
An adult man from Southern Africa presented with progressive fatigue. Blood morphology showed marked basophilia and 21% myeloblasts, with flow cytometry supporting a provisional diagnosis of acute myeloid leukaemia with…
Hodgkin Lymphoma With Sarcoid-Like Reaction: Importance of Clinicopathological Correlation in Granulomatous Lymphadenopathy.
A 63-year-old man with systemic lymphadenopathy had a cervical lymph node biopsy showing epithelioid granulomas but no identifiable neoplastic cells, prompting an initial suspicion of sarcoidosis.
A case of immunofluorescence-negative light chain deposition disease diagnosed by mass spectrometry.
A 53-year-old man with kidney dysfunction and edema had nodular glomerular lesions on biopsy, but immunofluorescence did not show immunoglobulin or light-chain deposits.
Secondary pulmonary alveolar proteinosis mimicking progression of interstitial lung disease during treatment for adult-onset still's disease: An autopsy case report.
A 68-year-old woman with adult-onset Still’s disease-associated interstitial lung disease developed worsening respiratory failure while receiving immunosuppressive therapy, despite apparent control of systemic…
SF3B1-mutated MDS coexisting with β-thalassemia trait: A case report and literature review focused on diagnostic distinction from acquired β-thalassemia.
An 81-year-old man presented with fatigue and fever, and testing showed microcytic anemia. Bone marrow morphology and molecular studies identified SF3B1-mutated myelodysplastic syndrome (MDS) alongside β-thalassemia…
Increased mean corpuscular hemoglobin concentration: A case report as an early clue of chronic severe hyponatremia.
An 81-year-old woman was admitted after three days of altered mental status. Her complete blood count showed a markedly elevated mean corpuscular hemoglobin concentration (MCHC) of 369 g/L; the blood smear showed…
Relapsed/refractory PBML complicated with failed platelet implantation and mixed infection after allo-HSCT: A case report.
A 48-year-old woman had refractory non-germinal-center diffuse large B-cell lymphoma arising in the bone marrow, with p53 overexpression, a complex karyotype, and hemophagocytic lymphohistiocytosis.
Anticoagulation with the mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat).
This Phase I randomised controlled trial programme evaluated two mechanistically distinct factor XI/FXIa monoclonal antibodies as potential anticoagulants, using in vitro assays, nonhuman primates and healthy…
Fatal haemophagocytic lymphohistiocytosis and atypical haemolytic uraemic syndrome following coronavirus disease 2019 infection.
A previously healthy woman in her early 30s developed rash, fever and arthralgia three weeks after SARS-CoV-2 infection, followed by rapidly progressive multiorgan failure.
Idiopathic multicentric Castleman disease in an HIV-positive child.
A preadolescent girl with HIV presented with fever and unilateral facial and neck swelling. Examination showed generalised lymphadenopathy, hepatosplenomegaly, hypertension and haematuria, initially suggesting…
In vitro correction of venom-induced coagulopathy in Daboia russelii envenomation demonstrated using tranexamic acid-modified rotational thromboelastometry.
A man in his late 40s presented soon after Russell’s viper envenomation with local signs and a prolonged modified Lee and White clotting time, despite normal prothrombin and activated partial thromboplastin times.
T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.
Successful treatment of hairy cell leukemia with TP53 abnormality using cladribine combined with low-dose rituximab: a case report and literature review.
An elderly man with classical hairy cell leukemia (HCL) had BRAF V600E positivity, a TP53 deletion detected by fluorescence in situ hybridization, and bone marrow fibrosis.
Infection burden in mismatched unrelated donor hematopoietic cell transplantation: results from the ACCESS trial.
The ACCESS trial evaluated infection burden in 268 adult patients undergoing HLA-mismatched unrelated donor hematopoietic cell transplantation (HCT) with posttransplant cyclophosphamide (PTCy) for graft-versus-host…
Hepatitis A-associated oxidative haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency with co-inherited sickle cell trait.
A young male presented with pruritus, nausea, and jaundice following travel to West Africa, lacking hepatitis A vaccination.
Presumed transdermal superwarfarin toxicity in a pest control worker.
A man in his early 60s presented with dyspnoea and a 2-3 month history of spontaneous mucocutaneous bleeding. Laboratory tests showed unmeasurably elevated INR and activated partial thromboplastin time.
Haemophagocytic lymphohistiocytosis triggered by Kikuchi-Fujimoto disease: a diagnostic challenge.
A man in his 40s presented with fever, confusion, a widespread erythematous rash, weight loss, and generalized lymphadenopathy over three weeks.
Early-onset VEXAS syndrome mimicking orbital cellulitis and successfully treated with allogeneic hematopoietic stem cell transplantation.
A 25-year-old male presented with recurrent fever, weight loss, arthralgia, and symptoms resembling orbital cellulitis. Imaging revealed orbital soft tissue inflammation, while laboratory tests showed macrocytic anemia…
Navigating the unexpected: management of incidental severe Factor V deficiency in term pregnancy.
A primigravida was found to have severe Factor V deficiency (<1% activity) during routine preoperative evaluation for an elective caesarean section, despite being asymptomatic and having no bleeding history.
Reduced venesection requirement as a clue to occult colorectal cancer in hereditary haemochromatosis.
A man in his late 70s with hereditary haemochromatosis experienced an unexpected cessation of his usual venesection for iron management, despite no gastrointestinal symptoms or anemia.
Fatal drug-induced liver injury in the setting of abemaciclib therapy for metastatic breast cancer.
A Hispanic woman in her mid-60s with metastatic ER+/HER2- breast cancer developed severe mixed hepatocellular-cholestatic injury one month after starting abemaciclib with letrozole.
Efficacy and safety of erythrocytapheresis in chronic mountain sickness: a randomised controlled trial protocol (ESCAPE-CMS).
This randomized controlled trial protocol investigates the efficacy and safety of erythrocytapheresis in patients with chronic mountain sickness (CMS), a condition affecting over 4 million individuals at high altitudes.
Interference of iron deficiency in glycated hemoglobin testing and its clinical implications: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of iron deficiency anemia (IDA) and latent iron deficiency (LID) on glycated hemoglobin (HbA1c) concentrations.
N-acetylcysteine mouthwash for prevention of oral mucositis in hematopoietic cell transplant recipients: a double-blind randomized controlled trial.
This double-blind randomized controlled trial evaluated the efficacy of N-acetylcysteine (NAC) mouthwash in preventing oral mucositis (OM) in 106 hematopoietic cell transplant (HCT) recipients.
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