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1821 articles
September 202624
Oncological impact of adjuvant chemotherapy after rectal cancer excision in the era of FOLFIRINOX-based TNT: A pooled post-hoc analysis of GRECCAR4-PRODIGE23.
This multicenter randomized controlled trial analyzed the impact of adjuvant chemotherapy (AC) on oncological outcomes in patients with locally advanced rectal cancer (LARC) following total neoadjuvant therapy (TNT) or…
Quality of life in patients with RAS wild-type metastatic colorectal cancer treated mFOLFOXIRI + panitumumab versus FOLFOXIRI: A prespecified secondary analysis of the phase II VOLFI AIO-KRK 0109 trial.
This phase II randomized controlled trial evaluated health-related quality of life (HRQoL) in 105 patients with RAS wild-type metastatic colorectal cancer receiving mFOLFOXIRI + panitumumab versus FOLFOXIRI.
First-line camrelizumab plus chemotherapy followed by camrelizumab-apatinib maintenance for ES-SCLC: a single-arm phase II study.
This single-arm phase II trial evaluated first-line camrelizumab plus platinum-etoposide followed by camrelizumab-apatinib maintenance in treatment-naïve patients with extensive-stage small-cell lung cancer.
Prognostic impact of high-grade transformation in low-grade B-cell lymphomas: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled overall-survival data from 38 datasets in 35 studies comparing high-grade transformation (HGT) of low-grade B-cell lymphoma with non-transformed low-grade lymphoma or de…
Activin pathway inhibition and rapid progression of malignancy in pulmonary arterial hypertension: A case series and hypothesis.
The report describes malignancies occurring in patients with pulmonary arterial hypertension (PAH) treated with sotatercept, an activin-pathway inhibitor.
Positive Effect of Methylphenidate for Cancer-Related Cognitive Impairment: A Pilot Randomized Trial.
This pilot randomized, double-blind, placebo-controlled trial assessed methylphenidate (MPH) for cancer-related cognitive impairment in women who had completed breast cancer treatment at least six months earlier and had…
Short course versus conventional interventional radiotherapy (brachytherapy) regimen in locally advanced cervical cancer: A randomized clinical trial.
This randomized clinical trial compared a one-week versus conventional three-week high-dose-rate interventional radiotherapy (brachytherapy) schedule in patients with stage IB2–IVA cervical cancer receiving definitive…
Validation of the newly introduced Deauville score 5a for patients treated for advanced-stage classic Hodgkin lymphoma.
This randomized controlled trial evaluated the prognostic value of the newly defined Deauville score 5a in patients with advanced-stage classical Hodgkin lymphoma (AS-cHL) after two cycles of treatment.
Pregnancy in a patient with metastatic functioning midgut neuroendocrine tumor receiving lanreotide after peptide receptor radionuclide therapy.
A pregnant patient with a metastatic neuroendocrine tumor of the ileocecal valve and carcinoid syndrome was treated with lanreotide after undergoing peptide receptor radionuclide therapy and debulking surgery.
Assessment of the role and effectiveness of nurse-led multimodal intervention in the rehabilitation of dysphagia in patients with brain tumors.
This randomized controlled trial evaluated the effectiveness of a nurse-led multimodal intervention for dysphagia rehabilitation in 120 brain tumor patients.
Improved quality of life and prolonged survival with add-on homeopathic treatment in patients with non-small cell lung cancer: a prospective, randomized, placebo-controlled, double-blind, three-arm, multicenter study.
This multicenter, randomized, placebo-controlled trial evaluated the effects of add-on homeopathic treatment on quality of life (QoL) and survival in 98 patients with stage IV non-small cell lung cancer (NSCLC).
Response to alemtuzumab-based therapy and long-term survival after allogeneic transplantation in T-Cell prolymphocytic leukemia: a systematic review and meta-analysis of proportions.
This systematic review and meta-analysis evaluated the response to alemtuzumab-based therapy and long-term survival after allogeneic hematopoietic cell transplantation (allo-HCT) in adults with T-cell prolymphocytic…
Robotic repeat hepatectomy for recurrent liver tumors: a systematic review of contemporary evidence and technical strategies.
Repeat hepatectomy is a potentially curative treatment for selected patients with recurrent liver malignancies but is technically demanding because of adhesions, distorted anatomy, and limited operative working space.
Comparative analysis of robotic- and endoscopic-assisted minimally invasive nipple-areola complex-sparing mastectomy for breast cancer: a meta-analysis with subgroup analyses.
This meta-analysis compared perioperative and oncologic outcomes of robotic- and endoscopic-assisted nipple-sparing mastectomy (NSM) versus conventional open NSM in breast cancer patients.
Early versus late closure of protective ileostomy after rectal cancer surgery.
This systematic review and meta-analysis evaluated the timing of protective ileostomy closure after rectal cancer surgery, comparing early closure (≤ 30 days) to late closure (≥ 12 weeks) in 387 patients.
ENCERT: A Multisite Phase 1 Trial Using Everolimus in Combination With Nelarabine, Cyclophosphamide, and Etoposide in Relapsed T-Cell Lymphoblastic Leukemia/Lymphoma.
This multisite Phase 1 trial assessed the safety and efficacy of everolimus combined with nelarabine, cyclophosphamide, and etoposide in children and young adults with relapsed/refractory T-cell acute lymphoblastic…
Genetic basis of pancreatic steatosis: a systematic review of comparison between African and non-African populations.
This systematic review examined genetic factors associated with pancreatic steatosis in African versus non-African populations, analyzing data from over 120,000 participants.
Triplet chemotherapy with Gemcitabine, Nab-paclitaxel, and S-1 achieves high response and conversion rates in advanced pancreatic cancer: A multicenter phase II study (GeNeS1S trial).
This multicenter phase II study evaluated the efficacy and safety of triplet chemotherapy with Gemcitabine, Nab-paclitaxel, and S-1 in 30 patients with advanced pancreatic cancer.
Impact of center-level protocol adherence on neoadjuvant treatment outcome in pancreatic ductal adenocarcinoma.
This multicenter phase III trial analyzed the impact of chemotherapy dose reductions and protocol adherence on event-free survival (EFS) in 260 patients with resectable and borderline resectable pancreatic ductal…
177 Lu-FAPI-2286 Radioligand Therapy in Refractory Scalp Melanoma.
A 66-year-old man with inoperable scalp melanoma that had not responded to immunotherapy was assessed for 177Lu-DOTATATE therapy.
Antibody-drug conjugate therapy in a renal transplant patient with bladder cancer: A case report.
A 61-year-old male renal transplant recipient developed recurrent bladder cancer while on immunosuppressive therapy. Initial treatment included transurethral resection and epirubicin instillations, but recurrence…
Sintilimab‑related cystitis/ureteritis in high‑grade endometrial stromal sarcoma: A case report and structured literature review.
A 44-year-old woman with high-grade endometrial stromal sarcoma developed severe urinary symptoms after three cycles of sintilimab combined with nab-paclitaxel and carboplatin.
18 F-FDG PET/CT-visualised immune-related hepatitis after immune checkpoint inhibitor combination treatment in a patient with metastatic melanoma.
A patient with metastatic melanoma underwent combination immunotherapy with ipilimumab and nivolumab. During a scheduled 18 F-FDG PET/CT scan to evaluate treatment response, immune-related hepatitis was identified due…
Cone-Beam Computed Tomography Imaging of Primary Non-Hodgkin Lymphoma of the Jaws: A 6-Case Series.
This case series examined six patients with histopathologically confirmed primary non-Hodgkin lymphoma (NHL) of the jaws, who initially presented with symptoms such as paresthesia, tooth mobility, and facial swelling.
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