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755 articles
May 202624
Malignancy in Pediatric Hyperfunctioning Thyroid Nodules: A Case Report and Literature Review.
A 12-year-old boy presented with a left-sided thyroid nodule following cervical swelling. Laboratory tests indicated suppressed TSH levels, while fT4 and fT3 were normal.
A Cost-Utility Analysis of LISTEN: Low-Intensity Mental Health Support via Telehealth-Enabled Network for Diabetes Distress.
This randomized controlled trial evaluated the cost-effectiveness of the LISTEN program, a low-intensity mental health support via telehealth for adults with diabetes distress.
SGLT-2 Use and Hypoglycemic Ketoacidosis.
A patient presented with severe hypoglycemic nondiabetic ketoacidosis, a rare variant of diabetic ketoacidosis. The diagnostic challenge arose due to the absence of hyperglycemia, which is typically expected in such…
Long-term cardiometabolic effects of early institutionalization and foster care: Evidence from the Bucharest Early Intervention Project.
This randomized controlled trial investigated the long-term cardiometabolic effects of early institutionalization and foster care in 139 young adults (mean age 22.6 years) from the Bucharest Early Intervention Project.
Central congenital hypothyroidism caused by TSHB gene mutation: a case report.
A 44-day-old infant presented with cyanosis and hypotonia, alongside macroglossia, jaundice, and a holosystolic murmur. Despite a negative neonatal screening for congenital hypothyroidism, thyroid function tests…
Treatment of androgenetic alopecia in transgender people receiving testosterone therapy with sublingual minoxidil: A randomized, double-blind, placebo-controlled clinical trial.
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of sublingual minoxidil in treating mild androgenetic alopecia in transgender individuals undergoing testosterone therapy.
Efficacy of combined supplementation of vitamins A/D/K1/K2 on the growth and development of preterm infants: A randomized controlled trial.
This randomized controlled trial investigated the effects of combined supplementation of vitamins A and K2 on the growth and skeletal development of 86 preterm infants.
Anti-pituitary-specific transcription factor-1 hypophysitis developing after thymoma resection: a case report with review of literature.
A 42-year-old woman developed anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis with deficiencies in growth hormone, prolactin, and thyrotropin following thymectomy for a WHO type B2 thymoma.
68 Ga-DOTATOC PET/CT in the Evaluation of Carney Triad Spectrum Tumors With an Associated Adrenal Adenoma.
A 40-year-old woman suspected of having Carney triad underwent 68 Ga-DOTATOC PET/CT for disease evaluation. Imaging revealed pulmonary chondromas with minimal tracer uptake, a DOTATOC-avid lesion suggestive of…
Early Enteral Levothyroxine as Rescue Therapy in Cardiac Surgery Patients With Delayed Neurologic Recovery: A Randomized Trial.
This randomized controlled trial evaluated early enteral levothyroxine as a rescue therapy for delayed neurologic recovery in 70 adults post-cardiac surgery.
Preoperative Preparation With Selective versus Nonselective Alpha-Adrenoceptor Blockade for Pheochromocytomas and Paragangliomas: A Systematic Review and Updated Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of nonselective alpha-blockers (NAB) versus selective alpha-blockers (SAB) for preoperative preparation in patients with pheochromocytomas and…
Effectiveness of sodium-glucose cotransporter 2 inhibitors in patients with metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Prehospital identification of hypoglycemia-induced seizure using a smartphone-linked continuous glucose monitoring application.
A 37-year-old man with type 1 diabetes experienced a generalized tonic-clonic seizure while shopping. His son used a smartphone app linked to the patient's continuous glucose monitoring (CGM) device to identify a…
Safety and efficacy of ashwagen (a standardized withania somnifera extract) in stress and anxiety with hypertension and associated cardiometabolic risk factors: a randomized, placebo-controlled trial.
This randomized, double-blind, placebo-controlled Phase III trial evaluated the safety and efficacy of Ashwagen®, a standardized Withania somnifera extract, in 60 patients with stress, anxiety, and pre-existing…
Letrozole Treatment in Idiopathic Peripheral Precocious Puberty Without Diagnosis of McCune-Albright Syndrome: A Case Report.
A girl with idiopathic peripheral precocious puberty presented with premature thelarche, recurrent vaginal bleeding, and elevated estradiol levels, alongside ultrasound findings of ovarian cysts.
The effect of metformin on perinatal outcomes in pregnant women with type 2 diabetes differs by baseline insulin requirements.
This randomized controlled trial analyzed the impact of metformin on perinatal outcomes in 785 pregnant women with type 2 diabetes, focusing on baseline insulin requirements.
Serial assessment of NT-proBNP and high-sensitivity cardiac troponin with glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes: Insights from EXSCEL.
This randomized controlled trial from the EXSCEL study evaluated the prognostic value of NT-proBNP and high-sensitivity cardiac troponin I in 4,292 adults with type 2 diabetes receiving exenatide or placebo.
Quality of life in primary aldosteronism, medical vs surgical treatment: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the impact of treatment on quality of life (QoL) in patients with primary aldosteronism (PA) undergoing either unilateral adrenalectomy (ADX) or medical treatment with…
Prevalence of cardiometabolic diseases among ART-naïve people with HIV: A global systematic review and meta-analysis.
This systematic review and meta-analysis assessed the global prevalence of cardiometabolic diseases (CMDs) among ART-naïve people with HIV (PWH).
Maternal Overnutrition in Pregnancy Predicts Greater Body Mass Index Gains in Offspring by Early Midlife: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed whether maternal pre-pregnancy BMI (ppBMI) and gestational weight gain (GWG) are associated with offspring adiposity in adulthood, and whether associations differ by…
Low Weight Loss Response to Incretin Analogs: A Systematic Review.
This systematic review examined factors associated with low or absent weight loss among people treated with GLP-1 and GIP analogs for type 2 diabetes or obesity.
Semaglutide improves markers of cardiovascular risk in people with HIV.
This phase II clinical trial investigated the effects of semaglutide on cardiovascular risk markers in 36 adults with HIV and metabolic dysfunction.
Effects of repeated periods of high-intensity interval training on myocardial function in patients with metabolic syndrome: A 16-month follow-up.
This randomized controlled trial investigated the effects of two periods of high-intensity interval training (HIIT) on myocardial function in 88 middle-aged patients with metabolic syndrome over 16 months.
The Acute Effects of Interrupting Prolonged Sitting With Regular Activity Breaks on Postprandial Glucose and Insulin in Adults: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed acute laboratory-based randomized crossover trials comparing prolonged sitting with short activity breaks in adults.
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