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1821 articles
September 202624
Vimseltinib for patients with tenosynovial giant cell tumor: A multicenter, open-label, phase 2 trial.
This multicenter, open-label, phase 2 trial evaluated the safety and efficacy of vimseltinib in adults with tenosynovial giant cell tumor (TGCT) not amenable to surgery.
Case report of an unusual cecal metastasis of a primary cervical squamous cell carcinoma.
A patient with cervical squamous cell carcinoma presented with cecal metastasis, identified as focal wall thickening and a cystic lesion via PET/CT.
Population Pharmacokinetics and Exposure-Response Analyses of Savolitinib Alone or in Combination With Osimertinib in Patients With Locally Advanced or Metastatic Solid Tumors.
This Phase II clinical trial analyzed the population pharmacokinetics of savolitinib in 998 patients with advanced solid tumors.
Manual, digital, and AI tumour-infiltrating lymphocyte scoring: a secondary analysis of the APHINITY randomised trial.
This secondary analysis of the phase 3 APHINITY trial evaluated manual, digital, and AI-based scoring of stromal tumour-infiltrating lymphocytes (sTILs) in 4262 patients with early-stage HER2-positive breast cancer.
High-dose radiotherapy in patients with high-risk prostate cancers treated with long-term androgen deprivation therapy (GETUG AFU 18): a randomised, phase 3 trial.
This multicenter, open-label, randomized phase 3 trial evaluated the impact of dose-escalated radiotherapy (80 Gy) versus standard radiotherapy (70 Gy) on progression-free survival in 505 men with high-risk prostate…
SHR-A2102, a nectin-4 directed antibody-drug conjugate, in patients with pretreated advanced solid tumours: a multicentre, single-arm, phase 1 trial.
This multicentre, single-arm phase 1 trial evaluated the safety and preliminary activity of SHR-A2102, a nectin-4 directed antibody-drug conjugate, in 395 patients with pretreated advanced solid tumours.
Ifebemtinib plus garsorasib in previously treated metastatic colorectal cancer with KRAS G12C mutation: a multicentre, randomised, phase 1b/2 trial.
This multicentre, randomised phase 1b/2 trial evaluated the combination of ifebemtinib and garsorasib in patients with previously treated metastatic colorectal cancer harboring the KRAS G12C mutation.
Adjuvant alectinib versus chemotherapy in resected ALK-positive non-small-cell lung cancer (ALINA): health-related quality-of-life and safety outcomes from a randomised, open-label, phase 3 trial.
The ALINA trial, a phase 3 randomized controlled trial, evaluated adjuvant alectinib versus chemotherapy in patients with resected ALK-positive non-small-cell lung cancer (NSCLC).
Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.
The HARMONi trial evaluated the efficacy and safety of ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after progression on EGFR TKI…
Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.
The EMERALD-3 study evaluated the efficacy and safety of combining STRIDE (tremelimumab and durvalumab) with or without lenvatinib and transarterial chemoembolisation (TACE) in patients with embolisation-eligible…
Percutaneous Cervical Cordotomy for Refractory Cancer Pain With General Anesthesia and Neuromonitoring: A Case Report.
A 54-year-old woman with metastatic gallbladder carcinoma presented with severe unilateral abdominal pain unresponsive to standard treatments.
Risk of Liver Cancer From Major Causes Compared to Smoking and Lung Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the risk of liver cancer associated with HBV, HCV, HDV, MASH, and alcohol consumption compared to smoking and lung cancer.
Machine Learning Models for Predicting Pain, Fatigue, Depression, Anxiety, and Malnutrition in Cancer Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated machine learning models for predicting pain, fatigue, depression, anxiety, and malnutrition in cancer patients.
Moraxella nonliquefaciens Keratitis Due to Ocular Surface Disease in a Patient Treated with Zanubrutinib for Mantle Cell Lymphoma.
A 73-year-old woman on zanubrutinib for mantle cell lymphoma presented with acute eye pain and vision loss. Examination revealed a corneal epithelial defect and stromal infiltrate, alongside bilateral epithelial…
A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma.
This Phase I trial evaluated the combination of duvelisib and oral azacitidine in 14 patients with relapsed/refractory T-cell lymphoma.
Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703).
The SOLARIS trial was a phase 3 randomized clinical trial involving 455 patients with previously untreated metastatic colorectal cancer (mCRC).
The Effects of Remote Ischemic Preconditioning on the Inflammatory Cytokine Response to Free Flap Head and Neck Reconstruction: A Randomized Controlled Trial.
This randomized controlled trial investigated the impact of remote ischemic preconditioning (RIPC) on inflammatory cytokine levels in 60 head and neck cancer patients undergoing free flap reconstruction.
Reassessing Radioactive Iodine Use After Thyroidectomy in Low-Risk Differentiated Thyroid Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of radioactive iodine (RAI) therapy in low-risk differentiated thyroid cancer (DTC) patients post-thyroidectomy.
Etomidate combined with TAPB in ovarian cancer surgery: A controlled study on hemodynamics and immune response.
This randomized controlled trial evaluated the effects of etomidate combined with transversus abdominis plane block (TAPB) on hemodynamics and immune response in 80 patients undergoing ovarian cancer surgery.
Clinical and autoantibody associations with malignancy in systemic sclerosis: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated factors linked to malignancy in 27,624 patients with systemic sclerosis (SSc).
Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.
A patient with melanoma developed abrupt-onset symptomatic hyperglycemia and mild ketosis after treatment with ipilimumab and nivolumab, indicating immune checkpoint inhibitor-induced diabetes (ICI-D).
The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial.
This randomized controlled trial evaluated the impact of genotype-informed personalized cancer risk estimates (GRE) versus standard lifetime cancer risk estimates (SRE) on decisional conflict in women with BRCA1/BRCA2…
A Multicentre Phase II Study of Trifluridine/Tipiracil in Recurrent/Metastatic Platinum-Resistant Nasopharyngeal Carcinomas.
This multicenter Phase II study evaluated the efficacy and safety of trifluridine/tipiracil (FTD/TPI) in 35 patients with recurrent/metastatic platinum-resistant nasopharyngeal carcinoma.
Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer.
This network meta-analysis evaluated the efficacy and safety of bisphosphonates in reducing skeletal-related events in 14,934 patients with bone metastases from breast cancer.
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