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793 articles
December 20259
Severe Hypercholesterolemia Caused by Mesalazine Which Is a Key Drug of Ulcerative Colitis.
A patient with ulcerative colitis developed severe hypercholesterolemia after starting mesalazine, a first-line treatment for the disease. The report attributed the hypercholesterolemia to mesalazine.
Open-Label, Phase 2a Pilot Study Evaluating the Efficacy and Tolerability of Topical Mesalamine Treatment in Adult Patients With Active Eosinophilic Esophagitis.
This open-label, phase 2a pilot clinical trial evaluated the efficacy and tolerability of topical mesalamine in adults with active eosinophilic esophagitis (EoE).
Global epidemiology of diabetes and prediabetes in lean or non-obese patients with NAFLD: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis estimated the global prevalence of diabetes and prediabetes among people with lean or non-obese non-alcoholic fatty liver disease (NAFLD).
Trofinetide-Induced Enterocolitis Syndrome in a Child with Rett Syndrome.
A young girl with genetically confirmed Rett syndrome developed emesis, pallor, and lethargy after two months of trofinetide treatment.
Sustained Virologic Response Following a Shortened Course of Direct-Acting Antiviral Therapy in an HIV/HCV Co-Infected Patient With Previous Treatment Experience: A Case Report.
A 47-year-old treatment-experienced man with HIV and chronic HCV had completed 10 weeks of sofosbuvir-velpatasvir before starting sofosbuvir-velpatasvir-voxilaprevir.
Hepatocellular carcinoma with macrovascular invasion: Review and survival meta-analysis of initial local therapy using minimal prognostic criteria.
This PRISMA-guided systematic review and meta-analysis assessed overall survival after initial local therapies, rather than systemic therapy, for hepatocellular carcinoma with macrovascular invasion.
Efficacy and Safety of Auricular Acupressure for Insomnia in Patients With Functional Dyspepsia: A Randomized Controlled Trial.
This randomized controlled trial evaluated auricular acupressure (AA) for insomnia in patients with functional dyspepsia (FD), comparing treatment at the ear concha with sham acupressure at the earlobe.
Acute liver failure as the first symptom of childhood systemic lupus erythematosus: a case report and review of the literature.
A 9-year-old Chinese girl presented with acute liver failure as the initial manifestation of systemic lupus erythematosus (SLE), without typical skin or joint features.
Stool-based methylated syndecan-2 test and fecal immunochemical test for advanced colorectal neoplasia screening in the Chinese population: A multicenter randomized noncomparative study.
This multicenter randomized noncomparative study assessed stool-based methylated Syndecan-2 (mSDC2) testing versus fecal immunochemical testing (FIT) for advanced colorectal neoplasia screening among Chinese adults aged…
November 20254
Patients With Gastroparesis Symptoms After Gastric Electrical Stimulation With and Without Tube Feedings.
This prospective, nonrandomized, open-label study compared gastric electrical stimulation (GES) outcomes in 311 patients with gastroparesis symptoms, with and without jejunostomy tube feedings.
Empirical Antifungal Therapy Improves Survival in Patients With Acute-on-Chronic Liver Failure With Suspected Invasive Fungal Infections: A Pragmatic Randomized Trial.
This pragmatic, parallel-group randomized trial compared empirical antifungal therapy at enrolment with diagnostic- or biomarker-driven pre-emptive therapy in 216 hospitalized patients with acute-on-chronic liver…
Nebokitug, an Anti-chemokine (C-C Motif) Ligand 24 Monoclonal Antibody, in Patients With Primary Sclerosing Cholangitis: A Phase 2 Study.
SPRING was a multicentre, randomised, double-blind, placebo-controlled phase 2 trial of intravenous nebokitug in patients with large-duct primary sclerosing cholangitis (PSC).
Dupilumab Improves Multiple Aspects of Dysphagia Symptoms in a Randomized Trial of Eosinophilic Esophagitis.
This randomized controlled trial evaluated dupilumab for eosinophilic esophagitis (EoE), a chronic inflammatory esophageal disease in which dysphagia is a common symptom among adults and adolescents.
October 20252
The influence of intermittent fasting on body metrics, lipid profile, and physical performance in young and middle-aged men.
This randomized controlled trial assessed five months of intermittent fasting, four days per week, in 40 active men aged 23–28 or 46–59 years.
Oral semaglutide for weight loss and liver fibrosis in overweight and obesity: A randomized controlled trial.
This randomized, open-label, controlled trial compared oral semaglutide plus diet and activity counselling with counselling alone in adults with overweight or obesity without diabetes.
September 20251
August 20252
Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.
This Mendelian randomization analysis used genome-wide association study summary data to assess whether genetic liability to gastroesophageal reflux disease (GERD) was causally related to six mental disorders.
Physical activity among people with an inflammatory bowel disease: a systematic review of antecedents.
This systematic review synthesized research on factors associated with physical activity among people with inflammatory bowel disease (IBD), including differences between Crohn’s disease and ulcerative colitis.
June 20251
May 20251
April 20251
March 20252
Efficacy of a CBT Self-Help App (Zemedy) Versus an Education, Relaxation, and Mindfulness App for IBS: Results from Post-Treatment, 3-Month, and 6-Month Follow-Up.
This randomized controlled trial compared the Zemedy self-help cognitive behavioral therapy (CBT) app with an active app providing education, lifestyle management, relaxation, and mindfulness for people with irritable…
Effect of Remote Counseling on Screening Uptake in the First-Degree Relatives of Colorectal Cancer Patients: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed remote counseling to promote colorectal cancer screening among first-degree relatives of people with colorectal cancer.
February 20251
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