Trending archive
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1845 articles
July 202624
SKYSCRAPER-01: Tiragolumab in Combination With Atezolizumab in Previously Untreated PD-L1-High, Locally Advanced, Unresectable or Metastatic Non-Small Cell Lung Cancer.
The SKYSCRAPER-01 study evaluated tiragolumab combined with atezolizumab in 521 patients with untreated, locally advanced unresectable or metastatic PD-L1-high non-small cell lung cancer.
The Effect of Food and the Proton Pump Inhibitor Rabeprazole on Binimetinib Pharmacokinetics in Healthy Participants.
This randomized controlled trial assessed the impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of binimetinib in healthy participants.
DNA Methylation Profiling of Pediatric Ectomesenchymoma Supports Embryonal Rhabdomyosarcoma-Like Epigenetic Identity.
This report details two cases of ectomesenchymoma, a rare pediatric tumor with both rhabdomyoblastic and neuroectodermal features. Genetic analysis revealed RAS-pathway mutations in both tumors.
Vinorelbine and low-dose cyclophosphamide as maintenance therapy in the treatment of Ewing sarcoma rationale for the international INTER-EWING-1 trial for Ewing sarcoma patients.
This systematic review evaluated the feasibility of maintenance therapy for Ewing sarcoma (ES) using vinorelbine and low-dose cyclophosphamide.
Renal Ewing Sarcoma Mimicking Neuroblastoma: A Multitracer PET/Scintigraphic Imaging Pitfall.
A 6-year-old boy presented with a left suprarenal mass initially suspected to be neuroblastoma. An inconclusive biopsy led to further imaging, where I-131 mIBG scintigraphy showed no uptake, Ga-68 DOTANOC PET/CT…
Pre-therapeutic PSMA PET Imaging Biomarkers Demonstrate Prognostic Value in Patients Undergoing [ 177 Lu]Lu-PSMA Therapy: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the prognostic value of pre-therapeutic PSMA PET imaging biomarkers in 2993 patients undergoing [177 Lu]Lu-PSMA therapy for metastatic castration-resistant prostate…
MRI radiomics for predicting pathological complete response in breast cancer: a systematic review of current evidence and limitations.
This systematic review evaluated MRI radiomics models for predicting pathological complete response (pCR) in breast cancer, analyzing 35 studies.
Beyond Pathological Complete Response: Long-term Outcomes in Esophageal and Esophagogastric Junction Adenocarcinoma After Multimodal Therapy-A Systematic Review and Individual Patient-Data Meta-Analysis.
This systematic review and individual patient-data meta-analysis compared long-term outcomes after neoadjuvant chemotherapy (nCT) versus chemoradiotherapy (nCRT) in patients with esophageal or esophagogastric junction…
Acute Toxicity With Trastuzumab Emtansine and Concurrent Radiotherapy: Non-Consecutive Case Series.
The authors describe ten patients with HER2-overexpressing breast cancer who developed enhanced toxicity when radiotherapy was given concurrently with, or close in sequence to, trastuzumab emtansine (T-DM1).
Systematic Review of AI-Driven Applications for Screening Nasopharyngeal Carcinoma Using MRI.
This systematic review evaluated the diagnostic performance of AI applications for screening nasopharyngeal carcinoma (NPC) using MRI, analyzing 38 studies involving 23,398 patients.
Effects of Hippocampal Avoidance on Anxiety in Patients With Nasopharyngeal Carcinoma Undergoing Intensity-Modulated Radiotherapy: A Single-Center, Single-Arm, Prospective Clinical Trial.
This single-center, single-arm prospective clinical trial evaluated the impact of hippocampal avoidance (D 40 < 15 Gy) on anxiety in 37 patients with nasopharyngeal carcinoma undergoing intensity-modulated radiotherapy…
Successful staged endoscopic treatment of multiple gastrointestinal varices caused by oxaliplatin-induced sinusoidal obstruction syndrome.
A 71-year-old man developed non-cirrhotic portal hypertension after oxaliplatin-based adjuvant chemotherapy for rectal cancer.
Multimodal approach enables R0 resection in advanced gastric adenocarcinoma with enteroblastic differentiation complicated by portal vein tumor thrombus.
A 73-year-old woman with stage IV gastric adenocarcinoma with enteroblastic differentiation (GAED) had portal vein tumor thrombus (PVTT).
Phase II Multicenter Clinical Trial of Intraoperative Molecular Imaging with Abenacianine During Lung Cancer Surgery.
This multicenter phase II clinical trial evaluated intraoperative near-infrared molecular imaging with abenacianine in patients undergoing surgery for known or suspected lung cancer.
Awareness is not enough: global evidence on breast cancer knowledge and self- screening practices among young women.
This systematic review examined breast cancer knowledge and self-screening practices among women aged 15-30. Despite fair general awareness, knowledge of risk factors and screening methods was limited, leading to low…
The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature.
This systematic review evaluated the role of chemotherapy in pediatric myoepithelial carcinoma (MEC) across 21 studies involving 40 patients.
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review.
This systematic review evaluated the role of natural killer (NK) cells in pediatric soft tissue sarcomas (pSTS), focusing on their presence, activity, and therapeutic potential.
On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi-Center Phase-III Randomized Clinical Trials.
This study analyzed hierarchical composite endpoints (HCEs) in two Phase III randomized clinical trials in pediatric supportive care.
Multicenter randomized effectiveness/implementation trial of a digital self-management support tool to improve the quality of life during adjuvant hormonal therapy for patients with early breast cancer: The HOPE trial.
The HOPE trial is a multicenter randomized controlled trial assessing a digital self-management support tool for patients with hormone receptor-positive early breast cancer undergoing adjuvant hormonal therapy.
Romiplostim for chemotherapy induced thrombocytopenia in pediatric cancers.
This investigator-initiated, open-label randomized trial at a tertiary centre in India evaluated prophylactic romiplostim in 93 children aged 1–14 years with AML, non-Hodgkin lymphoma, or solid tumours receiving…
Cerebrovascular involvement in Erdheim-Chester disease: a case report and systematic literature review.
A patient presented with recurrent strokes attributed to intracranial vertebral and basilar artery wall stenosis, initially misdiagnosed as giant cell arteritis.
Ovarian reserve as a measure of adjuvant chemotherapy benefit in hormone receptor positive (HR-positive), HER2-negative, node-positive breast cancer in SWOG S1007 (RxPONDER).
The phase III RxPONDER trial evaluated the role of ovarian reserve markers in predicting the benefit of chemotherapy in premenopausal women with HR-positive, HER2-negative breast cancer.
Sampling performance of EUS-Guided fine-needle biopsy in pancreatic neuroendocrine tumors: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the sampling performance of EUS-guided fine-needle biopsy (FNB) in patients with suspected pancreatic neuroendocrine tumors (PNETs).
Five-year follow-up of OPTIC: long-term efficacy, safety, and mutation analyses of ponatinib in chronic-phase chronic myeloid leukemia from a randomized phase 2 trial.
This phase 2 randomized trial evaluated the long-term efficacy and safety of ponatinib in patients with chronic-phase chronic myeloid leukemia (CP-CML) over five years.
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