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1333 articles
September 202624
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
Performing lifestyle changes and reducing stroke risk: a process evaluation of a stroke prevention intervention.
This randomized controlled trial evaluated a stroke prevention intervention in Swedish primary healthcare, focusing on implementation processes and mechanisms of change among 122 high-risk participants.
Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post-hoc analysis of the CANVAS and CREDENCE trials.
This post-hoc analysis of the CANVAS and CREDENCE trials evaluated the relationship between urinary dipstick findings and UTI risk in 8614 participants with type 2 diabetes.
Methods for a Community-Engaged Randomized Trial for Urgency Incontinence.
The Beta-Agonist versus ONA Trial for Urgency Urinary Incontinence (BEST) is a multicenter, single-blinded randomized trial comparing the efficacy of beta-agonist medication and onabotulinumtoxinA injections in female…
Perioperative Offloading for Diabetic Foot Ulcers: A Systematic Review and Evidence Synthesis.
This systematic review evaluated perioperative offloading strategies for diabetic foot ulcer (DFU) management, synthesizing evidence from 15 publications, including guidelines and expert consensus.
Prognostic Models for Predicting the Severity and Mortality in People With Acute Pancreatitis - A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed how accurately four clinical scoring systems predict severe acute pancreatitis (SAP) and mortality in adults.
Sex differences in the efficacy, acceptability, and tolerability of antipsychotics in people with acute schizophrenia: individual participant data pairwise, dose-response, and network meta-analyses.
This individual participant data pairwise, dose-response, and network meta-analysis examined sex differences in antipsychotic efficacy, acceptability, and tolerability in adults with acute schizophrenia.
Implementation of Total Body Photography for Skin Cancer Early Detection: A Systematic Review.
This systematic review examined how total body photography (TBP) has been implemented and used for skin cancer detection and surveillance across healthcare settings.
Endoscopic Ultrasound-Guided Hepaticogastrostomy With Plastic Stent Versus Metallic Stent for Malignant Biliary Obstruction: A Meta-Analysis.
This meta-analysis evaluated the efficacy and safety of plastic versus metal stents in endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) for malignant biliary obstruction.
Uterosacral Versus Sacrospinous Ligament Suspension in Pelvic Organ Prolapse: An RCT.
This randomized controlled trial compared high uterosacral ligament suspension (HUSLS) and sacrospinous ligament fixation (SSF) in women undergoing vaginal hysterectomy for pelvic organ prolapse (POP).
Efficacy of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of pancreatic enzyme replacement therapy (PERT) in improving nutrient absorption in patients with exocrine pancreatic insufficiency (EPI).
Percutaneous catheter drainage versus needle aspiration for liver abscess: a systematic review and meta-analysis of efficacy and safety.
This systematic review and meta-analysis evaluated the efficacy and safety of percutaneous catheter drainage (PCD) versus needle aspiration (PNA) for liver abscesses in 1425 adults.
A meta-analysis of transjugular intrahepatic portosystemic shunt with or without embolization for esophageal and gastric variceal bleeding in decompensated liver cirrhosis.
This meta-analysis evaluated the efficacy of transjugular intrahepatic portosystemic shunt (TIPS) with or without embolization in 3079 patients with decompensated liver cirrhosis experiencing esophageal and gastric…
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
Intracardiac vs. transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of intracardiac echocardiography (ICE) versus transesophageal echocardiography (TEE) in 7671 patients undergoing catheter ablation for atrial…
Impact of EBV status and histology on patient outcomes with nivolumab-AVD vs BV-AVD in advanced classic Hodgkin lymphoma (S1826).
This phase 3 randomized controlled trial evaluated the impact of EBV status and histology on outcomes in patients with advanced classic Hodgkin lymphoma treated with nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD…
Does a Simple Touch Make a Difference? The Effect of Acupressure on Pain Scores in Infants Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled Trial.
This randomized, placebo-controlled trial evaluated acupressure in 60 infants aged 1–12 months with congenital heart disease undergoing cardiac catheterization.
Effectiveness of psychosocial counselling on treatment adherence among patients with a new tuberculosis diagnosis in primary care: a study protocol for a cluster-randomised controlled trial.
This study protocol outlines a cluster-randomised controlled trial aimed at evaluating the effectiveness of psychosocial counselling on treatment adherence among newly diagnosed tuberculosis patients in primary care…
Efficacy and safety of tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis evaluated the efficacy and safety of 14-day tegoprazan-amoxicillin dual therapy versus bismuth-containing quadruple therapy (BQT) for first-line Helicobacter pylori eradication…
Imaging biomarkers for cardiometabolic risk stratification in metabolic dysfunction-associated steatotic liver disease: incremental value of coronary artery calcification, epicardial adipose tissue, controlled attenuation parameter, and liver stiffness measurement beyond clinical scores.
This systematic review analyzed 16 observational studies involving 34,713 adults with metabolic dysfunction-associated steatotic liver disease (MASLD) to evaluate the association between MASLD and imaging biomarkers of…
Effect of early regional anesthesia on postoperative cognitive function and the perioperative stress response in patients with hip fractures: a randomized controlled trial.
This randomized controlled trial investigated the effect of anterior iliopsoas muscle space block (AIMSB) timing on postoperative delirium (POD) in 79 elderly patients undergoing total hip arthroplasty for fractures.
Repetitive Transcranial Magnetic Stimulation Combined With Median Nerve Electrical Stimulation for Severe Traumatic Brain Injury.
This randomized controlled trial investigated the effects of repetitive transcranial magnetic stimulation (rTMS) combined with median nerve electrical stimulation (MNS) in 86 patients with severe traumatic brain injury…
Coffee consumption and head and neck cancer risk: a dose-response and site-specific meta-analysis.
This meta-analysis examined the relationship between coffee consumption and head and neck cancer (HNC) risk across 30 studies.
Age and antiplatelet de-escalation after myocardial infarction in the TALOS-AMI trial.
This secondary analysis of the TALOS-AMI randomized trial evaluated the effects of de-escalating from ticagrelor to clopidogrel on clinical outcomes in patients after myocardial infarction, stratified by age.
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