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433 articles
September 202624
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
Clinical, economic, and quality-of-life outcomes of brexucabtagene autoleucel for the treatment of relapsed/refractory mantle cell lymphoma and B-cell acute lymphoblastic leukemia: A systematic literature review and meta-analysis.
This systematic literature review and meta-analysis evaluated the clinical, healthcare resource use, and quality-of-life outcomes of brexucabtagene autoleucel in adults with relapsed/refractory mantle cell lymphoma…
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes) associated with Castleman disease and latent tuberculosis: a diagnostic challenge.
A woman in her 40s presented with progressive multisystem disease, including chronic distal neuropathy, constitutional decline, lymphadenopathy, and serosal effusions.
Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia.
A woman in her 60s with masked polycythaemia vera (PV) presented with extensive splanchnic venous thrombosis and mesenteric ischaemia after 5 years of management with phlebotomy and aspirin.
When two rare diseases meet: atypical hemolytic uremic syndrome and alkaptonuria in two siblings.
Two brothers from a consanguineous family presented with recurrent episodes of atypical hemolytic uremic syndrome (aHUS) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
FAT1-associated membranous nephropathy after hematopoietic stem cell transplantation: a case report and review of the literature.
A 55-year-old man developed nephrotic syndrome 52 months post-allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia.
Rotational thromboelastometry guided transfusion in venom-induced consumptive coagulopathy following a haemotoxic snakebite.
A woman in her 30s presented with severe haemotoxic snake envenoming and venom-induced consumptive coagulopathy (VICC), leading to early multiorgan involvement.
Scleromyxedema-Associated Myopathy and Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS) as manifestations of Monoclonal Gammopathy of Clinical Significance (MGCS): a disease spectrum between autophagy dysfunction and inflammation.
This report discusses two patients with Scleromyxedema-Associated Myopathy (SAM) and one with Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS), both associated with Monoclonal Gammopathy of Clinical…
Refractory Acquired Thrombotic Thrombocytopenic Purpura in the Third Trimester of Twin Pregnancy: A Case Report.
A 29-year-old woman in her third trimester of a twin pregnancy presented with symptoms including palpitations, dyspnea, and oral bleeding, alongside severe thrombocytopenia.
Autologous Hematopoietic Transplantation Reduces Brain Inflammatory and Axoglial Damage Biomarkers in Multiple Sclerosis.
This Phase II multicenter clinical trial investigated the effects of autologous hematopoietic stem cell transplantation (AHSCT) on inflammatory and axoglial damage biomarkers in 24 patients with severe multiple…
Carfilzomib plus induction chemotherapy for children with relapsed or refractory acute lymphoblastic leukemia.
This phase II clinical trial evaluated the efficacy of carfilzomib combined with induction chemotherapy (CFZ-VXLD) in pediatric patients aged 1 month to <21 years with relapsed or refractory acute lymphoblastic leukemia…
Atypical Bullous Sweet Syndrome.
A 71-year-old male with acute myeloid leukemia presented with bullous Sweet syndrome after receiving pegfilgrastim and quizartinib.
Factor V Deficiency and Mechanical Valve Replacement: Challenges in Perioperative Hemostasis and Anticoagulation.
A 30-year-old woman with congenital factor V deficiency (baseline activity 18%) underwent mechanical aortic valve replacement and mitral valve repair due to infective endocarditis.
When A Fall Isn't Just a Fall: Delayed Diagnosis of Acquired Hemophilia A in a Nonagenarian Patient.
A 92-year-old woman presented with severe right lower extremity pain after recurrent ground-level falls. Imaging revealed bilateral lower extremity intramuscular hematomas.
ATM mutations in myelodysplastic neoplasms, acute myeloid leukemia, and myeloproliferative neoplasms: a systematic review.
This systematic review evaluated the impact of ATM mutations in myelodysplastic neoplasms (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN).
Vision loss as the first manifestation of isolated cns relapse in CML blast crisis during flumatinib maintenance therapy: A case report.
A 65-year-old male with chronic myeloid leukemia in complete remission presented with progressive vision loss, indicating isolated CNS relapse.
Electronic patient-reported outcome platforms used in hematological cancers: a systematic review.
This systematic review examined electronic patient-reported outcome measures (ePROMs) in hematological cancers, identifying 14 platforms from 18 studies.
First reported human Castellaniella defragrans bacteraemia: a case report.
An 82-year-old man with monoclonal B-cell lymphocytosis, later diagnosed with chronic lymphocytic leukaemia, presented with fever, confusion, and signs of sepsis.
Recurrent VTE in patients with thrombophilia after stopping anticoagulation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the risk of recurrent venous thromboembolism (VTE) after stopping anticoagulation in patients with hereditary and acquired thrombophilia.
Etuvetidigene Autotemcel for the Treatment of Wiskott-Aldrich Syndrome.
This multicenter clinical trial evaluated the safety and efficacy of etuvetidigene autotemcel (etu-cel) in patients with Wiskott-Aldrich syndrome, integrating data from two studies and an expanded-access program.
Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma.
This phase 1 multicenter study evaluated the safety and efficacy of anitocabtagene autoleucel (anito-cel), a BCMA-directed CAR T-cell therapy, in 40 patients with relapsed or refractory multiple myeloma.
Immune Thrombotic Thrombocytopenic Purpura: Diagnosis and Management.
A middle-aged patient with a history of immune-mediated thrombotic thrombocytopenic purpura (iTTP) presented with a relapse characterized by thrombocytopenia and microangiopathic hemolytic anemia.
Classic mantle cell lymphoma with aberrant immunohistochemical expression of Fc receptor-like 4/immunoglobulin superfamily receptor translocation-associated 1.
A patient diagnosed with classic mantle cell lymphoma (MCL) presented with typical clinical, morphologic, immunophenotypic, and genetic features.
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