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1022 articles
October 202624
Next-generation pharmacological strategies for Parkinson's disease: a systematic literature review of symptom management and disease modification.
This PRISMA 2020 systematic literature review assessed pharmacological and emerging therapeutic strategies for symptom management and disease modification in Parkinson disease.
The Effects of Multimodal Communication Treatment With Discourse and Group Activities via Telepractice on People With Severe Nonfluent Aphasia: A Case Study.
Two people with severe nonfluent aphasia—one with Broca’s aphasia and one with global aphasia—received 10 weeks of telepractice multimodal communication treatment.
Exploring the Neural Mechanisms of Acupuncture Stimulation in Autism Spectrum Disorder: Protocol for a Randomized, Sham-Controlled, Multimodal Neuroimaging Trial.
This protocol describes a randomized, sham-controlled, stratified 2×2 trial designed to examine brain differences associated with autism spectrum disorder (ASD) and the acute neural response to acupuncture.
Exercise modality and planned weekly exercise exposure for motor outcomes in Parkinson's disease: a systematic review, Bayesian network meta-analysis, and meta-regression.
This systematic review and Bayesian network meta-analysis synthesized 173 randomized trials of exercise in people with Parkinson’s disease, assessing motor symptoms, balance, walking speed, and Timed Up and Go (TUG).
Genetic Variants in Intracranial Atherosclerotic Disease: A Systematic Review and Targeted Meta-Analysis Highlighting the RNF213 rs112735431.
This systematic review and targeted meta-analysis examined genetic variants associated with intracranial atherosclerotic disease (ICAD) in human studies identified through September 2025.
Detection of MOG-IgG and MOG-IgA in Maternal Breast Milk and Infant Blood in MOGAD: A Case Report.
A mother with MOG antibody-associated disease had persistently elevated plasma MOG-IgG, with a transient decrease in early pregnancy.
Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial.
This Phase IIb pilot randomized controlled trial assessed the feasibility, acceptability, and appropriateness of an 8-week supervised aerobic exercise program for adults with epilepsy aged 18-65 years.
Two siblings presented with spastic paraplegia and psychomotor retardation with or without seizures with HACE1 variants: A case report and literature review.
Two siblings from a nonconsanguineous Chinese family had infantile-onset hypotonia, global developmental and motor delay, gait impairment, language delay, and dysarthria; the older sister also had recurrent febrile…
Efficacy of Kinesio tape for central facial paralysis: A prospective, randomized sham-controlled, single-blinded clinical trial.
This prospective, randomized, single-blind, sham-controlled trial evaluated Kinesio tape (KT) as an adjunct to routine rehabilitation in 121 adults after a first stroke with central facial paralysis.
Low-Frequency Repetitive Transcranial Magnetic Stimulation with Sensory Arousal Nursing for Post-Stroke Dysphagia.
This single-center, randomized, assessor-blinded study evaluated low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with sensory arousal nursing versus routine nursing in 160 patients with acute…
Stakeholder Perspectives on Digital Health Technologies in Poststroke Self-Management and Rehabilitation: Systematic Review Based on the NASSS Framework.
This systematic review synthesized stakeholder perspectives on digital health technologies (DHTs) for poststroke self-management and rehabilitation, mapping findings to the NASSS framework.
Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
This pooled individual-patient analysis of five international randomised controlled trials examined whether hematoma location modifies the effect of early intensive blood pressure lowering in acute intracerebral…
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
Efficacy and safety of PCSK9 inhibitors combined with statins in acute ischemic stroke: a systematic review and meta-analysis.
This systematic review and meta-analysis of randomized controlled trials compared PCSK9 inhibitors plus statins with statins alone in patients with acute ischemic stroke.
Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.
This systematic review examined associations between multimodal MRI markers of white matter hyperintensities (WMH) and cognition in adults with cerebral small vessel disease.
Contrasting clinical trajectories in two ALS patients with rare FUS variants: implications for variant interpretation, penetrance, and trial readiness.
The report describes two patients with amyotrophic lateral sclerosis (ALS) carrying rare FUS variants. Their clinical courses differed, despite the association of FUS-related ALS with relatively aggressive disease.
Trigeminal sensory neuropathy developing as a late complication after the treatment of surgically induced necrotizing scleritis following pterygium surgery: a case report and literature review.
A 31-year-old woman developed right-eye irritation, reduced vision, and photophobia after bilateral pterygium surgery. Examination showed melting of the conjunctival autograft with exposed sclera and a visible choroidal…
Varicella zoster virus meningitis with a dermatomal rash in immunocompetent hosts: a systematic review and novel case report.
A 44-year-old immunocompetent man presented with fever, severe headache, and a right-sided vesicular rash in the C4-C5 dermatomes. He was initially misdiagnosed with a tick-borne illness.
Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.
Orthostatic tremor (OT) is traditionally classified using tremor frequency and the presence of associated neurological signs.
Bobble-Head Doll Syndrome Caused by Aqueductal Web-Associated Obstructive Hydrocephalus in an Adult: A Case Report with Video.
A 24-year-old man developed progressive memory impairment, gait instability, urinary incontinence, and an irregular side-to-side (“no-no”) head tremor that improved with a sensory trick.
Intracerebral stimulation inducing emotions in SEEG: a systematic review.
This systematic review examined subjective emotional responses to direct intracerebral stimulation during SEEG, synthesizing 34 publications (21 cohort studies and 13 clinical cases) involving 2434 patients and 14,492…
Atypical presentations of Lhermitte's sign after treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Two patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma developed Lhermitte’s sign after chemoradiotherapy.
Fregoli syndrome in an adolescent with Moyamoya disease.
An early adolescent with known Moyamoya disease developed acute psychosis after a febrile illness accompanied by headache and vomiting.
Staged bilateral MR-guided focused ultrasound thalamotomy in a patient with cerebral cavernous malformations.
A man in his late 60s with medication-refractory essential tremor was found on preoperative MRI to have cavernous malformations in the left caudate head and basal ganglia, with an associated developmental venous anomaly…
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