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433 articles
September 202624
RENOIR phase 3 rituximab-lenalidomide vs rituximab as maintenance treatment in relapsed/refractory follicular lymphoma.
The RENOIR phase 3 trial evaluated rituximab plus lenalidomide (R2) versus rituximab alone (R) as maintenance therapy in older patients with relapsed/refractory follicular lymphoma.
Sirolimus for refractory/relapsed warm autoimmune hemolytic anemia and Evans syndrome: a prospective study.
This prospective, single-center clinical trial evaluated sirolimus in 78 adults with refractory or relapsed warm autoimmune hemolytic anemia (wAIHA) and Evans syndrome (ES).
Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.
The ENERGIZE-T trial evaluated the efficacy and safety of mitapivat in adults with transfusion-dependent α- or β-thalassaemia. This double-blind, randomised, placebo-controlled phase 3 trial involved 258 patients.
Haematopoietic stem cell transplant in a case of mucopolysaccharidosis IV with Fanconi anaemia and bone marrow failure.
A child diagnosed with mucopolysaccharidosis type IV and Fanconi anaemia presented with bone marrow failure requiring haematopoietic stem cell transplantation.
Pediatric hepatic sarcoidosis presenting as hypersplenism and portal hypertension.
A mid-childhood female presented with massive splenomegaly, pancytopenia, and portal hypertension, but without constitutional or respiratory symptoms.
Pseudo-negative serum protein electrophoresis due to IgM aggregation in a patient with Waldenström macroglobulinemia: A case report.
A 79-year-old male presented with 10 months of anemia and bilateral lower limb and testicular edema. Following serological testing, serum protein electrophoresis, and genetic analysis, he was diagnosed with Waldenström…
Extensive Neurolymphomatosis as the Sole Site of Relapse in Mantle Cell Lymphoma.
A 60-year-old man with mantle cell lymphoma developed acute neurological symptoms after achieving complete remission. 18F-FDG PET/CT and brain PET/MR showed multiple enlarged spinal roots or nerves with intense FDG…
Prognostic impact of high-grade transformation in low-grade B-cell lymphomas: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled overall-survival data from 38 datasets in 35 studies comparing high-grade transformation (HGT) of low-grade B-cell lymphoma with non-transformed low-grade lymphoma or de…
Delayed Diagnosis of Type 1 Gaucher Disease at Age 15 After Years of Mild Cytopenias and Splenomegaly: A Case Report and Long-Term Follow-Up.
A 15-year-old male with a history of mild splenomegaly and cytopenias since infancy was diagnosed with Type 1 Gaucher Disease after developing severe skeletal pain and fever.
Response to alemtuzumab-based therapy and long-term survival after allogeneic transplantation in T-Cell prolymphocytic leukemia: a systematic review and meta-analysis of proportions.
This systematic review and meta-analysis evaluated the response to alemtuzumab-based therapy and long-term survival after allogeneic hematopoietic cell transplantation (allo-HCT) in adults with T-cell prolymphocytic…
Late Endocrine and Organ Toxicities After Treosulfan-Based Conditioning in Pediatric Hematopoietic Cell Transplantation: A Systematic Review.
This systematic review evaluated late endocrine and organ toxicities following treosulfan-based conditioning in pediatric hematopoietic cell transplantation (HCT).
Survival After Hematopoietic Stem Cell Transplantation in Diamond-Blackfan Anemia Syndrome: The Role of Iron Overload-A Systematic Review.
This systematic review evaluated the impact of iron overload on mortality and complications after hematopoietic stem cell transplantation in patients with Diamond-Blackfan anemia syndrome.
ENCERT: A Multisite Phase 1 Trial Using Everolimus in Combination With Nelarabine, Cyclophosphamide, and Etoposide in Relapsed T-Cell Lymphoblastic Leukemia/Lymphoma.
This multisite Phase 1 trial assessed the safety and efficacy of everolimus combined with nelarabine, cyclophosphamide, and etoposide in children and young adults with relapsed/refractory T-cell acute lymphoblastic…
Blinatumomab-induced catastrophic immune effector cell-associated neurotoxicity with diffuse cerebral edema in a patient with ALL: Case report.
A 13-year-old boy with MLL-AF4-positive precursor B-ALL developed catastrophic neurotoxicity during blinatumomab therapy. After initially tolerating treatment, he experienced fever on day 13 of the second cycle, leading…
Multidisciplinary Collaborative Treatment of Mediastinal Castleman Disease: A Case Report.
A 28-year-old man presented with cough and hemoptysis, leading to the discovery of a mediastinal mass via chest CT. A bronchoscopy-guided biopsy indicated lymphoid tissue hyperplasia.
Pomalidomide plus bortezomib and dexamethasone for newly diagnosed multiple myeloma with renal impairment: Randomized phase II study (POM-MM-003).
This open-label, multicenter, randomized phase II study compared pomalidomide, bortezomib, and dexamethasone (PVd) with bortezomib and dexamethasone (Vd) in 82 patients with newly diagnosed symptomatic multiple myeloma…
Diffuse skeletal and bone marrow metastases mimicking plasma cell dyscrasia in advanced lung adenocarcinoma.
A man in his late 40s presented with chest pain, cough, and dyspnoea. Imaging showed left lung collapse and pleural involvement, confirmed as pulmonary adenocarcinoma via thoracoscopic biopsy.
Frontline therapies for adult patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia: a systematic literature review.
This systematic review evaluated 96 studies on frontline therapies for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL).
Anesthetic Management of Two Pregnant Patients With Chronic Myeloid Leukemia: Two Case Reports.
Two pregnant patients with chronic myeloid leukemia (CML) underwent individualized anesthetic management based on their disease status.
Readmission in patients with hematologic malignancies: A systematic review and meta-analysis.
This systematic review and meta-analysis quantified readmission rates across follow-up windows in patients with hematologic malignancies and assessed associated factors. It included 104 studies.
Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.
A 66-year-old immunocompetent man presented with a 5 cm left testicular mass. Histological analysis showed a diffuse proliferation of large atypical lymphoid cells with plasmablastic morphology.
Induction and extended consolidation with daratumumab, cyclophosphamide, bortezomib, lenalidomide, and dexamethasone in patients with high-risk multiple myeloma (OPTIMUM/MUKnine): 5-year follow-up of a multicentre, externally controlled, phase 2 trial.
The OPTIMUM trial, a multicentre, phase 2 study, evaluated the effects of intensified induction and extended consolidation therapy in 107 patients with high-risk multiple myeloma.
Extramedullary T-Lymphoblastic Blast Crisis in Chronic Myeloid Leukaemia: A Unique Cytologic Diagnosis Confirmed by Flow Cytometry.
A 40-year-old man presented with generalized lymphadenopathy, hepatosplenomegaly, anemia, and marked leukocytosis. Bone marrow examination indicated chronic phase chronic myeloid leukaemia (CML) with confirmed BCR::ABL1…
Successful Engraftment Following Second Cord Blood Transplantation After Graft Failure in a Child With Relapsed B-ALL.
A 9-year-old boy with relapsed B-cell precursor acute lymphoblastic leukemia experienced primary graft failure after his first umbilical cord blood transplantation due to low CD34-positive cell dose and significant HLA…
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