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433 articles
September 202612
Systemic amyloidosis diagnosed by labial salivary gland biopsy.
A man in his 60s presented with acute decompensating heart failure and was initially evaluated for cardiac amyloidosis. Due to difficulties in obtaining a tissue sample, he was referred for a labial salivary gland…
Cardiovascular disease and amyloidosis in phase III multiple myeloma trials: a systematic review of eligibility, screening and event reporting.
This systematic review evaluated phase III randomized controlled trials of multiple myeloma therapies, focusing on eligibility criteria related to cardiovascular disease (CVD) and amyloidosis.
Case Report and Retrospective Review of Acanthamoeba Encephalitis and Chronic Lymphocytic Leukemia, United States.
A patient with chronic lymphocytic leukemia (CLL) presented with Acanthamoeba encephalitis. The case highlights the association between CLL and Acanthamoeba infections, noting that CLL is the most common underlying…
Neoehrlichiosis Causing Hemolytic Anemia in Patients Treated with Rituximab, Norway, 2024-2025.
Three rituximab-treated patients in Norway presented with direct antiglobulin test-negative hemolytic anemia due to Neoehrlichia mikurensis infection.
A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma.
This Phase I trial evaluated the combination of duvelisib and oral azacitidine in 14 patients with relapsed/refractory T-cell lymphoma.
Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.
This systematic review and meta-analysis evaluated the effectiveness of convalescent plasma (CCP) in immunocompromised COVID-19 patients who remained positive for SARS-CoV-2 after anti-Spike monoclonal antibody (mAb)…
Amyloid-Like Immunoglobulin Deposition Neuropathy.
A case of amyloid-like immunoglobulin deposition neuropathy was presented, characterized by predominant neuropathic pain, skin changes, and progressive distal sensory neuropathy.
Type 1 Diabetes Driven by Residual Recipient T Cells After Hematopoietic Cell Transplantation: A Case Report.
A patient developed type 1 diabetes following haploidentical hematopoietic cell transplantation. Analysis revealed an expanded population of islet-specific CD4+ T cells in the recipient, predominantly restricted by…
Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.
This systematic review examined gonadal function, fertility, sexual health, and pregnancy outcomes in adults with iron overload disorders, including thalassaemias, hereditary haemochromatosis, and transfusion-dependent…
Wartime Occurrence of Severe Aplastic Anemia in Previously Healthy Military Service Members: A Case Series.
Three previously healthy military service members developed idiopathic severe aplastic anemia (SAA) during active duty, presenting with cytopenias and hemorrhagic symptoms.
Tandem Double Inversion Resolves the Structural Paradox Underlying Recurrent KAT6A::NCOA2 Fusion in Acute Myeloid Leukemia.
A case of acute myeloid leukemia (AML) presented with the rare KAT6A::NCOA2 fusion, typically associated with inv(8)(p11q13). Genomic profiling revealed an unexpected MTFR1::KAT6A rearrangement.
XY0206 targets FLT3-dependent resistance states in acute myeloid leukemia.
This phase I/II clinical trial evaluated XY0206 monotherapy in patients with relapsed or refractory acute myeloid leukemia (AML), alongside laboratory and animal studies of its FLT3-directed activity.
August 202612
Efficacy and Safety of Ropeginterferon Alfa-2b in Pregnant Women With Myeloproliferative Neoplasms: Case Series of Three Subtypes and Review.
This case series reports on four pregnancies in women with myeloproliferative neoplasms (MPNs), including prefibrotic myelofibrosis, essential thrombocythemia, and polycythemia vera.
Clinical features, genetic analysis, and efficacy evaluation of hematopoietic stem cell transplantation in a case of osteopetrosis caused by compound heterozygous variations in the TNFRSF11A gene: a case study.
A three-year-old Chinese girl with osteopetrosis presented with recurrent fractures, short stature, and macrocephaly. Radiological findings showed elevated bone mineral density and constricted medullary spaces.
Phase II Study of Posttransplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After HLA-Mismatched Unrelated Donor Reduced Intensity Transplantation: Results From the ACCESS Trial Expansion Cohort.
This prospective, multicenter phase II study evaluated posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease prophylaxis in adults receiving peripheral blood stem cell transplantation from…
VEXAS Syndrome:Report of One Case.
An elderly male presented with fatigue and fever, later developing macrocytic anemia, tracheal and bronchial wall thickening, polyarthritis, rashes, and elevated inflammatory markers.
Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated prothrombin complex concentrate (PCC) versus non-PCC strategies for warfarin reversal in left ventricular assist device (LVAD) recipients.
Successful treatment of refractory hemophagocytic lymphohistiocytosis complicating Epstein-Barr virus-positive classic Hodgkin lymphoma with rituximab.
A male in his early 70s with advanced EBV-positive mixed-cellularity classic Hodgkin lymphoma presented with cervical lymphadenopathy, fever, and hepatosplenomegaly.
Severe Plasmodium falciparum malaria with marked ADAMTS13 reduction and secondary microangiopathic features: A case report.
A 46-year-old man returning from Nigeria presented with severe Plasmodium falciparum malaria after 11 days of intermittent fever, jaundice, and dark urine.
Prevalence and Clinical Relevance of Antiphospholipid Antibodies in Ischemic Stroke: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined the prevalence of antiphospholipid antibodies (aPL) in patients with ischemic stroke. Among 9438 patients, the pooled prevalence of aPL seropositivity was 19.1%.
HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities.
HOPE Kids 2 was a phase 3, multicenter, double-blind, placebo-controlled randomized trial of voxelotor in children aged 2 to <15 years with sickle cell disease (HbSS/HbSβ⁰) and conditional cerebral blood flow velocities…
Long-Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single-Center Experience Involving Three Pediatric Patients.
Three pediatric patients with severe congenital protein C deficiency underwent liver transplantation, resulting in plasma protein C activity levels exceeding 64% post-surgery.
Risk factors for invasive yeast infections in adult patients with hematological malignancies and/or stem cell transplant: systematic literature review and meta-analysis.
This systematic review and meta-analysis examined risk factors for invasive yeast infections (IYI) in adults with hematological malignancies or undergoing hematopoietic stem cell transplantation.
Effect of adding umbilical cord blood derived stem cells to haploidentical stem cell transplant (haplo-cord) on post-transplant survival and graft-versus-host disease in patients with hematological malignancies: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the impact of adding umbilical cord blood-derived stem cells to haploidentical stem cell transplantation (haplo-cord) in patients with hematological malignancies.
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