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1002 articles
September 202624
The Use of Waivers of Guardian Permission in the United States for Pediatric Digital Health Intervention Research Since 2020: Systematic Review.
This systematic review examined the use of guardian permission waivers in pediatric digital health intervention research in the U.S. from 2020 to 2026.
Cervical aortic arch with severe left ventricular dysfunction in a neonate: successful repair using whole-body perfusion.
A neonate presented with a right cervical aortic arch, coarctation, and significantly reduced left ventricular function. Surgical intervention involved arch repair with aortic uncrossing, utilizing whole-body perfusion…
Increased ureagenesis revealing metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT.
This secondary analysis of the PEPaNIC RCT evaluated the effects of early versus late parenteral nutrition (PN) in critically ill children (newborn-17 years) in PICUs.
Outcomes of delayed CSF diversion protocol in Infants with lumbosacral myelomeningocele: impact of timing of presentation on hydrocephalus development and postoperative complications.
This controlled clinical trial evaluated the outcomes of a delayed cerebrospinal fluid (CSF) diversion protocol in 186 infants with lumbosacral myelomeningocele (MMC) across two centers in Iraq.
X-linked hypophosphatemic rickets: case report with perspectives and challenges.
This case report discusses three pediatric patients diagnosed with X-linked hypophosphatemic rickets (XLH), a genetic disorder linked to PHEX gene mutations.
Effect of Repositioning Frequency on Bilirubin Levels and Comfort in Neonates Receiving Phototherapy: A Randomized Controlled Trial.
This randomized controlled trial assessed the impact of repositioning frequency on bilirubin levels and comfort in neonates undergoing phototherapy.
Kaposiform haemangioendothelioma presentation in hand in a paediatric patient.
A young female patient presented with progressive swelling and discoloration of the pulp of her right middle finger. Initially misdiagnosed as chronic osteomyelitis, further evaluation confirmed the diagnosis of…
Parental awareness, attitudes and decision-making of off-label use in children: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated parental awareness and attitudes towards off-label medication use in children. In seven studies, the pooled parental awareness rate was found to be 20.2%.
Giant Mesenteric Cyst: A Case Series.
This report details two pediatric cases of mesenteric cysts. A 10-month-old male presented with abdominal distension and intermittent non-bilious vomiting, while a 5-year-old boy exhibited severe abdominal distension…
Acceptance and perceived efficacy of intraoral versus extraoral photobiomodulation for oral mucositis prevention in pediatric patients.
This randomized controlled trial evaluated the acceptance and perceived efficacy of intraoral (IO) versus extraoral (EO) photobiomodulation therapy for preventing oral mucositis in 32 pediatric oncology patients.
A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer.
This phase 2 randomized controlled trial assessed the pharmacokinetics, pharmacodynamics, efficacy, and safety of oral netupitant combined with oral palonosetron (NEPA) in pediatric patients (< 18 years) undergoing…
Pharmacokinetics and Dose Optimization of Ethambutol in Children on First-Line Antituberculosis Therapy: An Individual Patient Data Meta-Analysis.
This meta-analysis examined the pharmacokinetics of ethambutol (EMB) in 220 children aged 0.2-15 years undergoing first-line tuberculosis therapy.
Serotype-specific Immunity and Association With Pneumococcal Carriage Following 3+1, 3+0, and 2+1 Schedules of 10-valent Pneumococcal Conjugate Vaccine.
This phase II/III randomized controlled trial in Vietnam evaluated the relationship between serotype-specific memory B cells, IgG, and opsonophagocytic responses following different schedules of the 10-valent…
Population Pharmacokinetics of Topical Timolol Maleate Gel in Healthy Volunteers and Infants With Superficial Infantile Hemangioma.
This study developed a population pharmacokinetic model for topical timolol maleate gel in healthy adults and infants with superficial infantile hemangioma.
A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.
The CHANGE-pilot trial is a parallel-group, two-arm, pilot randomized controlled trial assessing the feasibility of the EJDeR intervention, a low-intensity cognitive behavioural therapy for parents of children treated…
A randomised, participant- and assessor-blinded, sham-controlled trial investigating acupuncture for disorders of gut-brain interaction in children (P-GAP).
This randomized, participant- and assessor-blinded, sham-controlled trial investigates the efficacy of acupuncture for disorders of gut-brain interaction (DGBIs) in 96 children aged 8-17 years.
Clinical effectiveness of Er, Cr: YSGG laser compared with conventional rotary instrumentation for caries removal in primary teeth: a randomized split-mouth clinical trial.
This randomized controlled trial evaluated the effectiveness of Er, Cr: YSGG laser versus conventional rotary instrumentation for caries removal in 90 children aged 6-10 years.
The wider expansion of pediatric robotic urology: exploring the patterns of adoption in complex bladder reconstruction.
Robotic surgery is increasingly used in pediatric urology, particularly for moderate-complexity procedures such as pyeloplasty and ureteral reimplantation.
Phase III trial of sodium dichloroacetate for pyruvate dehydrogenase complex deficiency in children.
This Phase III randomized controlled trial evaluated sodium dichloroacetate (DCA) in 34 children with pyruvate dehydrogenase complex deficiency (PDCD).
Multidomain Intervention for Growth in Term Small-for-Gestational-Age Infants: A Randomized Clinical Trial.
This randomized clinical trial evaluated the impact of a multidomain intervention on growth and neurodevelopment in term small-for-gestational-age (SGA) infants in South Delhi, India.
Clinical development of human vaccine candidates against Shigella flexneri: a systematic review of clinical trials.
This systematic review evaluated the clinical evidence for human vaccine candidates against Shigella flexneri, focusing on safety, immunogenicity, and efficacy.
Rapid Review of the Brief Observation of Social Communication Change (BOSCC) Shows It Can Detect Behavioural Changes in Social Communication in Autism.
This rapid review evaluated the Brief Observation of Social Communication Change (BOSCC) in detecting behavioral changes in social communication among autistic children.
Asynchronous bilateral pulmonary pathology: left-sided congenital pulmonary airway malformation with contralateral malignant pleuropulmonary blastoma in an adolescent.
An adolescent boy with a history of left-sided congenital pulmonary airway malformation (CPAM) presented with dry cough, right-sided chest pain, and breathlessness.
Multiple hepatic artery pseudoaneurysms associated with visceral larva migrans: a rare cause of upper gastrointestinal bleeding in a child.
A 3-year-old girl presented with prolonged fever, abdominal pain, and haematemesis. Laboratory tests revealed anaemia, elevated eosinophils, jaundice, high serum IgE, and positive Toxocara serology.
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