FeaturedCase ReportEndocrinology
Primary Care Recognition of Rabson-Mendenhall Syndrome Despite Absence of Classical Diabetic Symptoms.
Am J Case RepSep 5, 2026
A 10-year-old girl presented with intermittent bilateral leg pain and excessive hunger, lacking classical diabetic symptoms. Examination revealed extensive acanthosis nigricans, moderate hirsutism, and dental defects.
Clinical pearl
Clinicians should consider genetic insulin resistance syndromes like Rabson-Mendenhall syndrome in patients with severe hyperinsulinemia and atypical features, even in the absence of classical diabetic symptoms.