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330 articles
October 202624
Wireless Home Blood Pressure Monitoring With Health Coaching for Hypertension Management at a Federally Qualified Health Center: Pilot Randomized Controlled Feasibility and Acceptability Study.
This 6-month, two-arm randomized pilot trial assessed feasibility and acceptability of wireless home blood pressure monitoring (HBPM) with health coaching among adults with uncontrolled or newly diagnosed hypertension…
Effectiveness and safety of atorvastatin/ ezetimibe fixed-dose combination in hypercholesterolemia: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared atorvastatin alone with atorvastatin/ezetimibe free-equivalent and fixed-dose combinations in people with hypercholesterolemia.
AI-Based Clinical Decision Support Systems in Primary Care: Systematic Review of Clinical Implementation.
This systematic review assessed the effectiveness and safety of AI-based clinical decision support systems (AI-CDSSs) used by health professionals in primary care, compared with usual care or non-AI decision support.
Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.
This systematic review of randomized controlled trials assessed supervised, face-to-face non-pharmacological interventions in adults with WHO-defined post-COVID-19 condition.
Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial.
This double-blind, randomized, placebo-controlled trial assessed whether Chios mastic provides additional cardiovascular benefits in 106 adults with stable, well-controlled hypertension.
Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta-Analysis.
This systematic review and meta-analysis estimated global adherence to antihypertensive medication among adults with hypertension.
Early Discharge Strategy Including Subcutaneous Furosemide in Hospitalized Heart Failure.
This multicenter, open-label, randomized active-controlled trial in the United Kingdom studied 172 patients hospitalized with heart failure who still required parenteral diuretics.
Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI: A Meta-Analysis of Randomized Trials.
This frequentist meta-analysis of four multicentre randomised trials compared immediate with staged complete revascularization in 2,651 patients with STEMI and multivessel disease.
Blood pressure targets in adults with hypertension.
This publication is a protocol for a Cochrane intervention review, not a report of completed results. It sets out to assess lower blood pressure targets (≤ 135/85 mmHg) versus standard targets (≤ 140 to 160/90 to 100…
Effect of web-based education on NIV-related side effects and insomnia severity in COPD patients using home NIV: a randomized controlled trial.
This randomized controlled trial evaluated web-based education about NIV-related side effects and insomnia management in 75 patients with COPD using home noninvasive ventilation.
Integrated management of atrial fibrillation with digital health support: a pooled analysis of individual participant data from the mAFA-II and MIRACLE-AF trials.
This pooled individual participant data analysis combined two prospective randomised trials of adults with atrial fibrillation: mAFA-II, which delivered ABC pathway care through a mobile app, and MIRACLE-AF, which used…
Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.
This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…
Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review.
This systematic review synthesised qualitative research on self-care among people living with HIV and hypertension or diabetes in low- and middle-income countries.
Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in heart failure: the DECISION trial.
This pre-specified analysis of the multicentre, randomised DECISION trial examined blinded withdrawal of long-term low-dose digoxin or placebo in patients with heart failure and reduced or mildly reduced ejection…
Etrasimod reduces circulating and mucosal inflammatory lymphocyte populations and alters innate immune and non-immune cell signatures in intestinal mucosa: ELEVATE UC phase 3 clinical data.
This analysis of the phase 3 ELEVATE UC randomised trials characterised blood and intestinal mucosal changes in patients with ulcerative colitis treated with etrasimod or placebo.
Real-World Effectiveness of AI-Enabled Clinical Decision Support in Primary Care: Systematic Review.
This systematic review synthesized real-world evaluations of clinician-facing AI-enabled clinical decision support in primary and ambulatory care, covering studies published from 2011 through 2025.
Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
This systematic review synthesised quantitative and qualitative evidence on treatment values, preferences, and perceived burden among adults with type 2 diabetes considering GLP-1 receptor agonists, SGLT-2 inhibitors…
Association between complement de-escalation and prognosis in sepsis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether reduced complement activation after treatment was associated with prognosis in patients with sepsis. Eleven studies were included.
Manual compared to automated closed-loop oxygen control strategies in hospitalised adults: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomised controlled trials comparing closed-loop oxygen control (CLOC) with manual adjustment in hospitalised adults receiving noninvasive oxygen.
Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial.
This randomized controlled trial examined whether eight weeks of betaine supplementation (3 g/d) affected mitochondrial-associated and redox measures in premenopausal women with overweight or obesity.
Daily sedation interruption versus no daily sedation interruption for critically ill adults and children requiring invasive mechanical ventilation.
This updated Cochrane systematic review and meta-analysis assessed daily sedation interruption (DSI) versus sedation strategies without interruption in critically ill adults and children receiving invasive mechanical…
Standardized Acupuncture Plus Modified Xiaoxuming Decoction for Acute Ischemic Stroke: A Randomized Controlled Trial.
This single-center, assessor-blinded randomized controlled trial enrolled adults with imaging-confirmed acute ischemic stroke within 72 hours and compared standard care with or without standardized acupuncture plus…
Temporal proximity to counseling is associated with longitudinal bedaquiline and antiretroviral therapy adherence in multidrug-resistant tuberculosis and HIV treatment.
This randomized controlled trial examined the relationship between counseling session timing and medication adherence in 76 participants receiving treatment for multidrug-resistant tuberculosis (MDR-TB) and HIV in South…
Native collagen matrix plus PHMB antimicrobial in hard-to-heal diabetic foot ulcers: results from the PREPARE randomised controlled trial.
The PREPARE prospective, multicentre randomised controlled trial compared purified native type 1 collagen extracellular matrix plus polyhexamethylene biguanide (PCMP) with standard care (SoC) alone in patients with…
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