Temporal proximity to counseling is associated with longitudinal bedaquiline and antiretroviral therapy adherence in multidrug-resistant tuberculosis and HIV treatment.
Xuan Lu, Jennifer Zelnick, Meng Zhao et al.
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In 30 seconds
This randomized controlled trial examined the relationship between counseling session timing and medication adherence in 76 participants receiving treatment for multidrug-resistant tuberculosis (MDR-TB) and HIV in South Africa. The study found that adherence to bedaquiline (BDQ) and antiretroviral therapy (ART) was highest immediately after counseling sessions, with adherence declining over time, particularly before the next session.
Key findings
- Adherence to BDQ was highest immediately after counseling, with a decline over time (β=-0.048, p=0.001).
- ART adherence also decreased after counseling sessions, with a significant decline noted before the next session (β=-0.032, p=0.020).
- Mean absolute error for BDQ adherence was 0.158 (95% CI 0.113-0.204).
- Mean absolute error for ART adherence was 0.180 (95% CI 0.170-0.191).
Why it matters
Understanding the dynamics of medication adherence in MDR-TB and HIV treatment is crucial for improving patient outcomes. This study highlights the potential impact of counseling timing on adherence, suggesting that optimizing counseling schedules may enhance treatment effectiveness.