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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchHematology

Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.

Blood AdvOct 15, 2026

This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…

Why it matters

The consistent association between positive LSC status and poorer survival at diagnosis and in remission suggests that LSC measurement may add prognostic information across disease stages.

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Also worth knowing

Clinical ResearchCardiologyOpen access

Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.

The phase 3, multicenter, randomized CHIPS trial compared cold-stored platelets (CSPs; up to 21 days) with room-temperature platelets (RTPs; up to 7 days) in pediatric and adult patients receiving platelet transfusions…

JAMAOct 13, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)Open access

SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.

This PRISMA-guided systematic review and meta-analysis assessed SOX10 immunohistochemical expression across primary salivary gland tumors. It included 35 studies comprising 1146 histological and 35 cytological samples.

Head Neck PatholOct 16, 2026Read summary
Clinical ResearchInfectious Diseases

Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.

This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…

J Infect DisOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

AI-Based Pathology Classifier Predicts Sensitivity to Enzalutamide in Metastatic Hormone-Sensitive Prostate Cancer: A Biomarker Analysis of the ENZAMET Trial.

This prespecified biomarker analysis of the randomised ENZAMET trial assessed whether a locked artificial intelligence pathology image classifier (APIC) identified differential overall-survival benefit from enzalutamide…

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchOncology (Medical)

Impact of Phosphatidylinositol 3-Kinase and B-Raf Mutations in Rat Sarcoma Wild-Type Metastatic Colorectal Cancer.

This systematic review and meta-analysis assessed whether PIK3CA and BRAF mutations were associated with outcomes among patients with RAS wild-type metastatic colorectal cancer receiving first-line EGFR inhibitor…

J Vis ExpOct 16, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Application of a concise video to improve patient understanding of tumor genomic testing in community and academic practice settings.

This multicenter clinical trial evaluated a 3–4 minute educational video for patients undergoing standard-of-care tumor genomic testing (TGT), across cancer types and academic and community settings.

PLoS OneOct 13, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)

Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.

Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.

Liver IntOct 15, 2026Read summary
Clinical ResearchCardiologyOpen access

Fibro-Inflammatory Signaling, Fibrosis, and Microvascular Ischemia as Convergent Translational Substrates of Sudden Cardiac Death in Hypertrophic Cardiomyopathy: A Systematic Review.

This systematic translational review examined whether fibro-inflammatory signaling, fibrosis, and microvascular ischemia converge as substrates for ventricular arrhythmia and sudden cardiac death in hypertrophic…

J Cardiovasc Transl ResOct 13, 2026Read summary
Clinical ResearchEndocrinology

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.

DiabetesOct 21, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Translational applications and clinical utility of organoids in ovarian cancer: a systematic review.

This systematic review synthesized 13 studies of patient-derived organoids (PDOs) in ovarian cancer, assessing feasibility, histological fidelity, and agreement between organoid drug sensitivity and clinical outcomes.

Cancer Chemother PharmacolOct 22, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

Molecular-genetic mechanisms of cerebral arteriovenous malformations: A systematic review of germline, somatic and experimental evidence.

This systematic review synthesised human genetic, molecular, and experimental evidence on cerebral arteriovenous malformation (AVM) formation, clinical course, and potential therapeutic targets.

Neurosurg RevOct 22, 2026Read summary

Showing 12 of 15 publications that cleared our clinical screen in the last 14 days.

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