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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchObstetrics & Gynecology

Outcomes of Mindful Mood Balance for Moms, online mindfulness-based cognitive therapy for perinatal depressive relapse prevention in the USA: a two-arm, single-blind, pragmatic randomised clinical trial.

Lancet Public HealthOct 21, 2026

This single-blind, pragmatic randomised clinical trial tested a web-based mindfulness-based cognitive therapy programme plus usual care against usual care alone in euthymic pregnant women with recurrent depression and…

Why it matters

Depressive relapse during pregnancy and postpartum is a significant public health concern. This trial suggests that an accessible, web-based psychological programme may reduce relapse risk when added to usual care for…

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Also worth knowing

Clinical ResearchPsychiatry

Digital Therapeutic Interventions for Suicide Prevention: A Systematic Review and Meta-Analysis of Their Effectiveness in Reducing Suicidal Ideation and Suicide Attempts.

This systematic review and meta-analysis synthesised randomized clinical trials of digital interventions for suicide prevention. Seventeen studies (N = 5.089) were included.

PsicothemaOct 24, 2026Read summary
Clinical ResearchPsychiatryOpen access

Efficacy and safety of GLP-1 receptor agonists for antipsychotic-related overweight and metabolic dysregulation: a systematic review and meta-analysis.

This systematic review and meta-analysis pooled randomized controlled trials of GLP-1 receptor agonists in adults receiving antipsychotic treatment for overweight or metabolic dysregulation.

Eur J Clin PharmacolOct 24, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

This systematic review of randomized controlled trials assessed supervised, face-to-face non-pharmacological interventions in adults with WHO-defined post-COVID-19 condition.

J Rehabil MedOct 19, 2026Read summary
Clinical ResearchOrthopedic Surgery

Psychological Factors Associated with Function and Health-Related Quality of Life Outcomes following Total Hip or Knee Arthroplasty: An Umbrella Review of Systematic Reviews.

This umbrella review synthesised high-quality evidence from systematic reviews on psychological factors associated with function and health-related quality of life after total hip or knee arthroplasty.

JBJS RevOct 19, 2026Read summary
Clinical ResearchPsychiatry

An Internet-Based Cognitive-Behavioral Program, With Telephone Support, Improves Pain, Disability and Emotional Well-Being in Adults With Chronic Pain: Randomized Controlled Trial of the Pain Course With 2-Year Follow-Up.

This randomised controlled trial evaluated an internet-delivered, cognitive-behavioral Pain Course with clinician support in adults with chronic pain living in Ireland.

Clin J PainOct 14, 2026Read summary
Clinical ResearchNeurology

Post-Stroke Depression and Determinants in Ethiopia; A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined the prevalence and determinants of post-stroke depression (PSD) in Ethiopia, combining findings from eight studies.

Int J Methods Psychiatr ResOct 13, 2026Read summary
Clinical ResearchInfectious Diseases

The dual burden of disease: Depression among patients with multidrug resistance tuberculosis in low-income and lower- middle-income countries: A systematic review and meta-analysis.

This systematic review and random-effects meta-analysis estimated depression prevalence and examined associated factors among patients with multidrug-resistant tuberculosis (MDR-TB) in low- and lower-middle-income…

PLoS OneOct 13, 2026Read summary
Clinical ResearchPsychiatryOpen access

Assessing the Impact of Metacognitive Therapy on OCD Severity and Beliefs: A Three-Wave Multisite RCT With Panel Mediation Analysis.

This multisite, assessor-blinded randomized controlled trial compared 12 weekly sessions of individual metacognitive therapy (MCT) with documented treatment as usual (TAU) in 76 adults with OCD receiving outpatient care…

Depress AnxietyOct 15, 2026Read summary
Clinical ResearchGeriatrics

Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial.

This nonblinded pilot randomized controlled trial assessed the feasibility and potential effectiveness of VOICE-COG, a personalized cognitive reablement program delivered through digital voice assistants, in adults aged…

JMIR AgingOct 23, 2026Read summary
Clinical ResearchPsychiatryOpen access

Randomized controlled trial of a group-based smoking cessation intervention for adults with serious mental illness.

This randomized controlled trial evaluated PARQuit in 99 adults with serious mental illness in the United States. Participants received 12 weeks of cessation counseling and pharmacotherapy and were assigned to…

Nicotine Tob ResOct 22, 2026Read summary
Clinical ResearchPsychiatryOpen access

Effects of transcranial direct current stimulation on nicotine use disorder: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed transcranial direct current stimulation (tDCS) for smoking-related outcomes in people with nicotine use disorder.

Nicotine Tob ResOct 22, 2026Read summary

Showing 12 of 37 publications that cleared our clinical screen in the last 14 days.

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