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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchPulmonology

A self-controlled case series to evaluate the effects of clinical trial eligibility criteria on biologic-associated reductions in severe asthma exacerbations: an analysis of the CHRONICLE study.

Eur Respir JOct 22, 2026Open access

This study examined whether eligibility criteria used in biologic trials identify adults with severe asthma who are more likely to benefit.

Why it matters

Trial eligibility rules shape both the populations studied and the applicability of results to routine care. These findings suggest that smoking history, prior exacerbations, and type 2 biomarkers may help identify…

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Also worth knowing

Clinical ResearchOncology (Medical)

The prognostic value of physical functioning on survival in patients with nonsmall cell lung cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis examined whether objectively measured physical functioning predicts survival in adults with nonsmall cell lung cancer (NSCLC), across surgical and nonsurgical treatment groups.

Eur Respir RevOct 21, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

This systematic review of randomized controlled trials assessed supervised, face-to-face non-pharmacological interventions in adults with WHO-defined post-COVID-19 condition.

J Rehabil MedOct 19, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Effectiveness of local ablative therapy combined with first-line tyrosine kinase inhibitors in epidermal growth factor receptor-mutated oligometastatic non-small cell lung cancer: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed local ablative therapy (LAT) plus first-line tyrosine kinase inhibitors (TKIs) versus TKI alone in patients with EGFR-mutated oligometastatic non-small cell lung cancer.

Clin Exp MetastasisOct 17, 2026Read summary
Clinical ResearchPulmonology

Interventions to increase participation in lung cancer screening programmes: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed interventions to improve informed choice and participation in low-dose CT lung cancer screening.

Eur Respir RevOct 21, 2026Read summary
Clinical ResearchPulmonologyOpen access

Effects of resistance training on subjective sleep quality, excessive daytime sleepiness, and quality of life in patients with obstructive sleep apnea: a secondary analysis from a randomized controlled trial.

This secondary analysis of a randomized controlled trial examined eight weeks of resistance training in 25 adults with moderate to severe obstructive sleep apnea.

Sleep BreathOct 20, 2026Read summary
Clinical ResearchPulmonology

Clinical Outcomes and Complications of Extracorporeal Membrane Oxygenation (ECMO) in Adult Patients With COVID-19 in Central and Eastern Europe: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis pooled observational studies of adults with COVID-19 treated with ECMO in Central and Eastern Europe. Twelve studies covered 802 patients from six countries.

Med Sci MonitOct 22, 2026Read summary
Clinical ResearchPulmonology

The effects of multiregional fascial mobilization on heart rate and physiological parameters in patients with obstructive sleep apnea: A randomized controlled trial.

This randomized controlled trial assessed the acute physiological effects of a 16-minute multiregional fascial mobilization protocol in 95 men with polysomnography-confirmed moderate-to-severe obstructive sleep apnea.

Medicine (Baltimore)Oct 16, 2026Read summary
Clinical ResearchCardiology

Safety and effectiveness of the Vertex Pulmonary Embolectomy System in acute intermediate-risk pulmonary embolism: the SPIRARE II pivotal trial.

SPIRARE II was a prospective, single-arm, multicentre pivotal trial evaluating the Vertex Pulmonary Embolectomy System for aspiration thrombectomy in patients with acute intermediate-risk pulmonary embolism.

EuroInterventionOct 19, 2026Read summary
Clinical ResearchOncology (Medical)

Efficacy and Safety of Necitumumab and Pembrolizumab Combination Therapy in Advanced Non-Small Cell Lung Cancer with ≥50% PD-L1 Expression: A Nonrandomized Phase II Trial.

This nonrandomized, multicenter, open-label, single-arm phase II trial evaluated first-line pembrolizumab plus necitumumab in 50 patients with previously untreated advanced NSCLC and PD-L1 tumor proportion score ≥50%.

Clin Cancer ResOct 15, 2026Read summary
Clinical ResearchPulmonology

Machine Learning, Radiomics, and Clinical Models Predicting Checkpoint Inhibitor Pneumonitis in Lung Cancer: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed machine-learning, radiomics, deep-learning, and clinical models for predicting checkpoint inhibitor pneumonitis in people with lung cancer.

J Vis ExpOct 13, 2026Read summary
Clinical ResearchPulmonologyOpen access

The Impact of Ambient Ozone Exposure on Respiratory Health in the U.S. Populations: A Systematic Review.

This systematic review synthesized U.S. epidemiologic and experimental studies published from 1980 to 2026 on acute and chronic ambient ozone exposure and respiratory health.

Curr Environ Health RepOct 17, 2026Read summary

Showing 12 of 20 publications that cleared our clinical screen in the last 14 days.

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