Trending Now

Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchOncology (Medical)

Osimertinib With or Without Chemotherapy in Advanced Non-Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations: A Randomized Clinical Trial.

JAMASep 8, 2026Open access

This phase 3 randomized clinical trial evaluated the efficacy and safety of osimertinib combined with chemotherapy versus osimertinib alone in 294 patients with advanced non-small cell lung cancer (NSCLC) harboring…

Why it matters

The findings suggest that combining osimertinib with chemotherapy may enhance treatment outcomes for patients with specific genetic mutations in advanced NSCLC, potentially guiding personalized treatment strategies.

Read summary

Also worth knowing

Clinical ResearchEndocrinology

Global prevalence of metabolic syndrome in adults with obstructive sleep apnea: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the global prevalence of metabolic syndrome (MetS) in adults with obstructive sleep apnea (OSA), analyzing data from 102 studies involving 34,013 adults across 28…

SleepSep 9, 2026Read summary
Clinical ResearchPulmonology

Comorbidities in clinical cohorts of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

This systematic review and meta-analysis examined the prevalence and impact of comorbidities in 606,398 patients with idiopathic pulmonary fibrosis (IPF).

Eur Respir RevSep 9, 2026Read summary
Clinical ResearchMedical Genetics

Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in adolescents and adults with cystic fibrosis and F508del-gating and F508del-residual function genotypes: results from an open-label extension study.

This phase 3 open-label extension study evaluated the long-term safety and efficacy of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) in 251 adolescents and adults with cystic fibrosis and F508del-gating or…

Ann Am Thorac SocSep 1, 2026Open accessRead summary
Clinical ResearchGastroenterology

Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.

This substudy of the REVISE trial evaluated the effects of pantoprazole in 532 mechanically ventilated patients with SARS-CoV-2.

BMJ OpenAug 31, 2026Open accessRead summary
Clinical ResearchPulmonology

Randomised controlled trial to assess the safety and efficiency of a self-contained sampling device/disposable bronchoscope system versus usual sampling procedure (RASECAL).

This multicenter randomized controlled trial evaluated the safety and efficiency of a closed bronchoscopy sampling system (Ambu bronchosampler) compared to standard sampling containers in 188 mechanically ventilated…

BMJ Open Respir ResAug 31, 2026Open accessRead summary
Clinical ResearchPulmonology

Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.

This systematic review and meta-analysis examined age-related changes in forced vital capacity (FVC) among over 365,000 adults without lung disease.

Eur Respir RevSep 9, 2026Read summary
Clinical ResearchOncology (Medical)

Daraxonrasib for Previously Treated RAS -Mutant Non-Small-Cell Lung Cancer.

This phase 1-2 multicenter trial evaluated the safety and efficacy of daraxonrasib in 136 patients with previously treated RAS-mutant non-small-cell lung cancer (NSCLC).

N Engl J MedSep 3, 2026Read summary
Clinical ResearchPulmonology

Low-dose vs standard-dose nintedanib at initiation in fibrosing interstitial lung disease: a target-trial emulation of treatment persistence and lung function.

This observational study emulated a randomized trial to compare the effects of initiating nintedanib at 100 mg vs 150 mg twice daily in 172 patients with fibrosing interstitial lung disease.

Ann Am Thorac SocSep 1, 2026Read summary
Clinical ResearchPulmonology

Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials.

This pooled analysis of the ALIENTO and ARNASA trials evaluated the efficacy of astegolimab, an anti-ST2 monoclonal antibody, in patients with chronic obstructive pulmonary disease (COPD) experiencing frequent…

Am J Respir Crit Care MedSep 1, 2026Open accessRead summary
Clinical ResearchPulmonology

Dupilumab in chronic obstructive pulmonary disease: a pooled analysis of emergency department visits, hospital admissions, and systemic corticosteroid use.

This pooled analysis from two phase III randomized controlled trials evaluated the impact of dupilumab on emergency department visits, hospital admissions, and systemic corticosteroid use in patients aged 40-85 with…

Am J Respir Crit Care MedSep 1, 2026Open accessRead summary
Clinical ResearchPulmonology

Clinical pharmacist-led intervention improves anxiety, depression and inhaler technique in budesonide/glycopyrronium/formoterol-using patients: A single-center prospective randomized cohort study.

This single-center prospective randomized cohort study evaluated the impact of a clinical pharmacist-led intervention on anxiety, depression, and inhaler technique in 100 patients using…

Pak J Pharm SciSep 1, 2026Read summary

Showing 12 of 50 publications that cleared our clinical screen in the last 14 days.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.