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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedCase ReportRheumatology

Systemic sclerosis presenting as recurrent pericardial effusion despite repeatedly negative multiplex antinuclear antibody results.

BMJ Case RepSep 7, 2026

A woman in her 70s presented multiple times with recurrent pericardial effusions, despite negative multiplex antinuclear antibody (ANA) results.

Clinical pearl

Clinicians should not rely solely on multiplex ANA screens; persistent clinical suspicion warrants further testing with HEp-2 indirect immunofluorescence and disease-specific antibodies.

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Also worth knowing

Case ReportNephrology

Rapidly progressive glomerulonephritis in rheumatoid arthritis: an early presentation of ANCA-associated vasculitis.

A 68-year-old man with newly diagnosed seropositive rheumatoid arthritis presented with rapidly progressive glomerulonephritis just six months after his arthritis diagnosis.

BMJ Case RepSep 2, 2026Read case
Case ReportOphthalmology

Severe vaso-occlusive lupus retinopathy: Purtscher-like retinopathy: a case report.

A 24-year-old female with systemic lupus erythematosus (SLE) developed blurred vision following COVID-19 infection, later presenting with fever, lymphadenopathy, seizures, and altered consciousness.

Medicine (Baltimore)Sep 4, 2026Read case
Case ReportHematology

Severe aplastic anemia as a rare autoimmune complication of ankylosing spondylitis: A rare case report.

A 42-year-old male with a history of ankylosing spondylitis presented with recurrent mucocutaneous bleeding, severe fatigue, and transfusion dependence.

Medicine (Baltimore)Sep 4, 2026Read case
Case ReportMedical Genetics

Clinical and immunological characterization of a child with a homozygous TBK1 kinase-domain truncation.

TBK1 is a serine-tyrosine kinase protein that transmits signals from pattern recognition receptors to the NF-κB pathway leading to production of Type 1 Interferons.

Immunol ResSep 7, 2026Open accessRead case
Case ReportOphthalmology

COMBINATION OF METHOTREXATE AND MYCOPHENOLATE MOFETIL FOR REFRACTORY UVEITIS AND SCLERITIS: A Case SERIES.

This case series involved six patients, five with uveitis and one with scleritis, all of whom had treatment-resistant conditions.

Retin Cases Brief RepSep 1, 2026Read case
Case ReportHematology

VEXAS Syndrome：Report of One Case.

An elderly male presented with fatigue and fever, later developing macrocytic anemia, tracheal and bronchial wall thickening, polyarthritis, rashes, and elevated inflammatory markers.

Zhongguo Yi Xue Ke Xue Yuan Xue BaoAug 30, 2026Read case
Case ReportNeurology

Life-threatening multisystem sarcoidosis with neurological, renal, ocular and autoimmune haemolytic manifestations treated with intravenous immunoglobulin, plasma exchange, cyclophosphamide and infliximab.

A patient with multisystem sarcoidosis presented with encephalopathy, acute tubulointerstitial nephritis, optic neuritis, and autoimmune hemolytic anemia, resembling a stroke.

BMJ Case RepSep 2, 2026Read case
Case ReportPediatrics

Recurrent incomplete Kawasaki disease with small-joint-predominant arthritis during the acute phase.

An adolescent boy presented on day 6 of illness with fever and left cervical lymphadenopathy, having a history of complete Kawasaki disease.

BMJ Case RepSep 2, 2026Read case

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