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Digest for Oct 21, 2026 – Oct 27, 2026
12 papersUpdated recently
Clinical Research

Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.

N Engl J MedOct 15, 2026

This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.

Key findings

  • Estimated 24-month event-free survival was 86% with ponatinib–blinatumomab versus 67% with imatinib–chemotherapy (P<0.001).
  • Survival with no measurable residual disease was 68% in the intervention group and 42% in the control group.
  • Complete hematologic response at the end of induction occurred in 94% versus 79%, respectively.
Specialty: HematologyView full text
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AllClinical ResearchCase Reports
Case ReportMedical GeneticsOpen access

Clinical manifestations of Armfield syndrome in females with heterozygous FAM50A variants and skewed X-chromosome inactivation.

A Spanish female patient presented with macrocephaly, global developmental delay, and leukoencephalopathy. Whole-exome sequencing identified a novel de novo heterozygous FAM50A variant, c.905 A > T (p.His302Leu).

Neurol SciOct 24, 2026Read case
Case ReportPediatricsOpen access

Varicella zoster vasculopathy presenting as bilateral subdural haematoma in an infant: case report of a rare case and literature review.

A 6-month-old boy developed chickenpox with fever, irritability, and a vesicular rash. Although the rash and fever resolved, he had persistent irritability, poor feeding, intermittent vomiting, developmental regression…

Childs Nerv SystOct 24, 2026Read case
Case ReportUrology

Robotic Totally Intracorporeal Bilateral Boari Flap Reconstruction for Complex Bilateral Ureteral Strictures: A Step-by-Step Technique.

A 42-year-old woman with complex bilateral mid- and distal ureteral strictures underwent robotic, totally intracorporeal bilateral Boari flap reconstruction.

Int Braz J UrolOct 23, 2026Read case
Case ReportUrology

Robot-Assisted Radical Prostatectomy in a Post-Enucleation Gland.

A 64-year-old man was found to have right-lobe ISUP grade 3 prostate adenocarcinoma after HoLEP for benign prostatic obstruction. PSA was 0.51 ng/mL, and MRI showed a 0.4 cm PI-RADS 4 lesion.

Int Braz J UrolOct 23, 2026Read case
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