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Digest for Sep 6, 2026 – Sep 12, 2026
12 papersUpdated recently
Clinical ResearchClinical ResearchOpen access

Osimertinib With or Without Chemotherapy in Advanced Non-Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations: A Randomized Clinical Trial.

JAMASep 8, 2026

This phase 3 randomized clinical trial evaluated the efficacy and safety of osimertinib combined with chemotherapy versus osimertinib alone in 294 patients with advanced non-small cell lung cancer (NSCLC) harboring…

Key findings

  • Median progression-free survival was 34.0 months for osimertinib plus chemotherapy versus 15.6 months for osimertinib alone.
  • The hazard ratio for progression-free survival was 0.44, indicating a significant benefit for combination therapy.
  • The incidence of grade 3 or higher treatment-related adverse events was higher in the combination group.
Specialty: Oncology (Medical)View full text
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AllClinical ResearchCase Reports
FeaturedCase ReportOncology (Medical)

Immune-checkpoint inhibitor-induced bullous pemphigoid in patients with metastatic renal cell carcinoma: two case reports and systematic review of the literature.

Acta OncolSep 9, 2026

Two patients with metastatic renal cell carcinoma developed bullous pemphigoid after treatment with immune-checkpoint inhibitors.

Clinical pearl

Clinicians should be vigilant for bullous pemphigoid in patients receiving immune-checkpoint inhibitors, especially after prolonged treatment, as early recognition can facilitate timely management.

Read case
Case ReportAnesthesiology

Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Block versus Interscalene Brachial Plexus Block for Analgesia After Arthroscopic Shoulder Surgery: A Randomized Non-Inferiority Clinical Trial.

This randomized non-inferiority trial was designed to verify whether ultrasound-guided infraspinatus-teres minor interfascial block (ITMB) could produce non-inferior postoperative analgesia in adult patients undergoing…

Drug Des Devel TherSep 3, 2026Open accessRead case
Case ReportNeurology

PHACE syndrome: a systematic literature review and illustrative case report of a patient with severe cerebrovascular and neurodevelopmental sequelae.

A 12-year-old girl with PHACE syndrome presented with a left V1-distribution facial hemangioma and significant cerebrovascular complications, including neonatal intraventricular hemorrhage, hydrocephalus, and a dural…

Neurol SciSep 4, 2026Open accessRead case
Case ReportObstetrics & Gynecology

Rudimentary horn pregnancy mimicking tubal ectopic pregnancy: a diagnostic dilemma.

A woman in her 20s presented with 6 weeks of amenorrhea and a positive urine pregnancy test. Transvaginal ultrasound suggested an ectopic pregnancy with a gestational sac in the right adnexa and an empty uterine cavity.

BMJ Case RepSep 9, 2026Read case
Case ReportPediatrics

Malignant pertussis in a young infant.

A young infant presented with malignant pertussis, characterized by extreme leucocytosis and respiratory failure, alongside additional bloodstream infections during hospitalization.

BMJ Case RepSep 8, 2026Read case
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