Prognosis of Patients with Lung Cancer Admitted to the Intensive Care Unit: A Systematic Review and Meta-Analysis.
Ahmed Elkhapery, Hazem Taifour, Chengu Niu et al.
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In 30 seconds
This systematic review and meta-analysis examined ICU, hospital and longer-term outcomes, and mortality predictors, among critically ill patients with lung cancer. It included 33 studies: 28 cohort studies (n = 4123) and five population-based studies (n = 82,475). Pooled ICU mortality was 46.4% (95% CI 41.0-51.8; n = 16,772), while pooled long-term mortality at 6-12 months was 73.5% (95% CI 68.2- 78.2; n = 84,008). Metastatic disease, poor performance status, organ-support requirements and higher severity scores were associated with mortality.
Key findings
- Pooled ICU mortality was 46.4% (95% CI 41.0-51.8; n = 16,772).
- Pooled hospital mortality was 51.9% (95% CI 46.9-56.9; n = 72,215).
- Pooled long-term mortality at 6-12 months was 73.5%, (95% CI 68.2- 78.2; n = 84,008).
- Mortality predictors included mechanical ventilation (RR 2.25, 95% CI 1.58-3.21) and vasopressor requirement (RR 1.95, 95% CI 1.54-2.46).
Why it matters
The findings quantify substantial short-term mortality and an even higher burden of death over the following 6-12 months in this population. Associations with metastatic disease, functional status, organ-support needs and illness-severity scores may help frame prognostic discussions, while the pooled estimates provide context for ICU outcomes across the included studies.
What to keep in mind
The review pooled observational cohort and population-based studies; the abstract does not report randomized evidence, and estimates may reflect differences among the included studies.