Sex influence on in-hospital and long-term prognosis of myocardial infarction with non-obstructive coronary artery disease: a systematic review and meta-analysis.
Cristian Herrera-Flores, Robin W M Vernooij, Javier Herrera-Flores et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of sex on mortality and major adverse cardiovascular events (MACE) in 42,870 patients with myocardial infarction with non-obstructive coronary artery disease (MINOCA). The study found no significant sex differences in in-hospital mortality (OR: 1.05) or all-cause death at follow-up (OR: 0.93). However, men had a lower risk of non-fatal stroke (OR: 0.77) during follow-up.
Key findings
- No sex differences in in-hospital mortality (OR: 1.05; 95% CI: 0.82-1.34).
- No significant differences in all-cause death at follow-up (OR: 0.93; 95% CI: 0.76-1.13).
- Men had a lower risk of non-fatal stroke during follow-up (OR: 0.77; 95% CI: 0.60-0.99).
- Women with MINOCA had lower in-hospital mortality compared to those with MI due to CAD (OR: 0.39; 95% CI: 0.21-0.72).
Why it matters
Understanding the influence of sex on clinical outcomes in MINOCA is crucial for risk stratification and management. This study suggests that sex does not significantly affect mortality or MACE, which may inform treatment approaches and patient counseling.