Neonatal Cardiac Tamponade Caused by a Pericardial Tufted Angioma: A Rare Cause of Fetal Pericardial Effusion and a Multidisciplinary Treatment Approach.
Burcu Büşra Acar Alkan, Osman Nuri Tuncer, Demet Terek et al.
✦ AI-curated · Sources linked
Case in brief
A term neonate with prenatal pericardial effusion developed recurrent cardiac tamponade despite drainage and medical therapy. Surgical exploration identified a pericardial lesion, and histology confirmed tufted angioma, a benign vascular tumor. The report describes treatment with sirolimus and vincristine as targeted therapy.
What made this case unusual
The tufted angioma involved the pericardium and presented as fetal effusion followed by recurrent neonatal tamponade—an exceptionally uncommon form of cardiac involvement.
Diagnostic / clinical pearl
When neonatal pericardial effusion recurs despite conventional treatment, consider a vascular tumor and pursue tissue diagnosis when appropriate.
Why it matters
The report highlights a multidisciplinary approach combining surgical exploration and histologic diagnosis with targeted therapy for this unusual cause of tamponade.