Triglyceride-glucose index as a novel predictor of major adverse cardiovascular events in patients with coronary revascularization: a meta-analysis of cohort studies.
Chunyu Zhang, Minghao Li, Lin Liu et al.
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In 30 seconds
This meta-analysis of cohort studies assessed whether the triglyceride-glucose (TyG) index was associated with cardiovascular outcomes after coronary revascularization. It included 12 studies and 9,973 participants. A high TyG index was associated with more major adverse cardiovascular events (MACEs) than a low index (RR 2.0, 95% CI 1.71-2.35), with substantial heterogeneity (I² = 76.2%). Associations were also reported in both coronary artery bypass grafting and percutaneous coronary intervention subgroups, and for all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, and repeat revascularization.
Key findings
- High TyG was associated with MACEs overall (RR 2.0, 95% CI 1.71-2.35; I² = 76.2%).
- In the CABG subgroup, high TyG was associated with MACEs (RR 2.10, 95% CI 1.80-2.45; I² = 20.9%).
- In the PCI subgroup, high TyG was associated with MACEs (RR 1.94, 95% CI 1.54-2.46; I² = 84.2%).
- The analysis also reported prognostic associations for all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, and repeat revascularization.
Why it matters
The findings suggest that the TyG index may help identify patients with higher cardiovascular risk after coronary revascularization. Its association with outcomes across both CABG and PCI populations makes it a potentially relevant risk marker, although the substantial heterogeneity in the overall and PCI analyses means the strength and consistency of the association warrant careful interpretation.
What to keep in mind
The evidence comes from cohort studies, so it establishes association rather than causation. Heterogeneity was substantial overall and in the PCI subgroup.