Organizing Pneumonia in a Patient with Pulmonary Transthyretin Amyloidosis.
Yutaka Tojo, Zenta Watanuki, Junko Sakurada et al.
✦ AI-curated · Sources linked
Case in brief
An 86-year-old retired tunnel construction worker with pleural plaques and chronic pleural effusion was evaluated for newly developed pulmonary infiltrates. Transbronchial lung biopsy showed organizing pneumonia alongside transthyretin amyloid deposits in the alveolar septa. Genetic testing identified wild-type transthyretin amyloidosis. The infiltrates partially resolved with corticosteroid therapy.
What made this case unusual
Organizing pneumonia was found together with transthyretin amyloid deposition in the alveolar septa, an association reported in few cases.
Diagnostic / clinical pearl
When evaluating organizing pneumonia, consider whether coexisting pulmonary transthyretin amyloid deposition may be relevant, particularly when biopsy demonstrates amyloid in the alveolar septa.
Why it matters
This case raises the possibility that transthyretin amyloidosis may be involved in the development of organizing pneumonia, although it does not establish causation.