Recurrence of peripartum cardiomyopathy in subsequent pregnancy stratified by left ventricular function: a systematic review and meta-analysis.
Hawani Sasmaya Prameswari, Cindya Perthy Iswandi, Jordan Budiono et al.
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In 30 seconds
This systematic review and meta-analysis examined the recurrence of peripartum cardiomyopathy (PPCM) in subsequent pregnancies among women with prior PPCM, stratified by left ventricular ejection fraction (LVEF). Among 266 women, relapse rates were similar in recovered (LVEF ≥50%) and non-recovered (LVEF <50%) groups (rate ratio 0.77). However, maternal mortality was significantly lower in the recovered group (1.7% vs 10.9%).
Key findings
- Relapse rates of PPCM were similar in recovered and non-recovered groups (RR 0.77).
- Maternal mortality was significantly lower in the recovered group (1.7% vs 10.9%; RR 0.27).
- Recovered group had a higher mean LVEF during subsequent pregnancy (mean difference 17.0).
- Greater likelihood of LV recovery in the recovered group (RR 2.07).
Why it matters
Understanding the risks associated with subsequent pregnancies in women with prior PPCM is crucial for optimizing maternal care. This study highlights the importance of LVEF in predicting maternal outcomes, although it emphasizes the need for comprehensive risk assessment.