Maternal Chikungunya virus infection and pregnancy outcomes: a global systematic review and meta-analysis of vertical transmission dynamics and associated morbidity.
Yan Guo, Yujie Xiang, Mengyuan Zheng et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the impact of maternal Chikungunya virus (CHIKV) infection on pregnancy outcomes, analyzing 57 observational studies. The study found a pooled vertical transmission rate of 18.1%, with significant increases during the third trimester (36.5%) and intrapartum period (49.1%). Maternal CHIKV infection was associated with a more than two-fold increased risk of adverse perinatal outcomes (OR = 2.28).
Key findings
- The vertical transmission rate of CHIKV was 18.1%, with a significant increase in the third trimester (36.5%).
- Adverse pregnancy outcomes occurred in 11.3% of infected women, with stillbirth rates at 22.0%.
- Neonatal mortality reached 6.9%, with feeding difficulties reported in 79.4% of affected neonates.
- Maternal CHIKV infection was associated with a more than two-fold higher risk of adverse perinatal outcomes (OR = 2.28).
Why it matters
Understanding the risks associated with maternal CHIKV infection is crucial for improving prenatal care and neonatal outcomes. Enhanced surveillance and assessment protocols can help mitigate the adverse effects of this infection in endemic regions.