Group B Streptococcus in African pregnancies: A systematic review and meta-analysis of its maternal rectovaginal colonization, vertical transmission, serotype distribution, and antimicrobial resistance.
Int J Infect DisApr 17, 2026 (epub)
Tsegaye Melaku, Zeleke Mekonnen, Gemeda Abebe et al.
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In 30 seconds
This systematic review and meta-analysis examined Group B Streptococcus (GBS) colonization and transmission in African pregnant women, analyzing data from 116 studies involving 53,770 participants. The study found a pooled prevalence of maternal rectovaginal GBS colonization at 18% and a vertical transmission rate of 47%. Notably, high antimicrobial resistance was observed for tetracycline (87%) and cotrimoxazole (75%).
Key findings
- Pooled prevalence of maternal rectovaginal GBS colonization was 18% (95% CI: 16%-20%).
- Vertical transmission rate of GBS was 47% (95% CI: 39%-55%).
- High antimicrobial resistance was noted for tetracycline (87%; 95% CI: 85%-88%) and cotrimoxazole (75%; 95% CI: 72%-78%).
- Serotypes V, Ia, and III were the most frequently detected among maternal isolates.
Why it matters
Understanding the prevalence and antimicrobial resistance patterns of GBS in pregnant women is crucial for developing effective prevention strategies and treatment protocols, particularly in regions with high colonization and transmission rates.