The effect of low-carbohydrate diets on serum concentration of soluble adhesion molecules: a systematic review and meta-analysis of randomized controlled trials.
Mahdieh Khodarahmi, Sanaz Mehrabani, Gholamreza Askari
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of low-carbohydrate diets (LCDs) on serum levels of adhesion molecules in adults. Analyzing data from nine randomized controlled trials with 333 participants, the study found that LCDs significantly reduced E-selectin concentrations by 3.95 ng/mL compared to controls (95% CI: -6.42 to -1.47; P = 0.002).
Key findings
- LCDs significantly reduced E-selectin concentrations by 3.95 ng/mL compared to control groups.
- No significant effects were observed on ICAM, VCAM, or P-selectin levels.
- The analysis included nine publications with a total of 333 participants.
- No heterogeneity was found in the results (I² = 0.0%).
Why it matters
Understanding the effects of dietary interventions on adhesion molecules is crucial, as they play a role in cardiovascular disease. This research suggests that LCDs may offer a beneficial effect on E-selectin levels, potentially influencing cardiovascular health.
What to keep in mind
Given limited studies and dietary heterogeneity, findings should be interpreted cautiously.